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- Central to maintaining a healthy epithelium are intestinal stem cells (ISCs), which are essential for replenishing the intestinal epithelium throughout an individual’s lifespan. Recent research has unveiled the intricate interplay between ISCs and their niche, which includes various cell types, extracellular components, and signaling molecules.
www.nature.com/articles/s12276-024-01179-1 - People also ask
WEBMar 1, 2024 · Central to maintaining a healthy epithelium are intestinal stem cells (ISCs), which are essential for replenishing the intestinal epithelium throughout an individual’s lifespan. Recent...
Roles of intestinal epitheli…
Introduction. The gastrointestinal tract is an organ that takes in food, digests it and …
Adult intestinal stem cells: cr…
30 Altmetric. Metrics. Key Points. Intestinal stem cells are responsible for the …
A growth factor-free culture …
The successful long-term maintenance of Lgr5 + ISCs with the two small …
Vedolizumab for the prevent…
Acute graft-versus-host disease (aGVHD) of the lower gastrointestinal (GI) tract is a …
See results only from nature.com
WEBFood and nutrition have a profound impact on organismal health and diseases, and tissue-specific adult stem cells play a crucial role in …
- Author: Gizem Calibasi-Kocal, Gizem Calibasi-Kocal, Omid Mashinchian, Yasemin Basbinar, Ender Ellidokuz, Chi...
- Publish Year: 2021
- Studies of gut stem cell maintenance
WEBAug 8, 2022 · Intestinal stem cells (ISCs) play an important role in maintaining intestinal homeostasis via promoting a healthy gut barrier. Within the stem cell niche, gut …
- DOI: 10.7150/ijbs.72600
- Published: 2022
- Publication: Int J Biol Sci. 2022; 18(13): 5185-5206.
WEBCentral to maintaining a healthy epithelium are intestinal stem cells (ISCs), which are essential for replenishing the intestinal epithelium throughout an individuals lifespan. …
WEB19 hours ago · The intestinal epithelium undergoes complete cellular turnover every 3–7 days, fueled by the continuous self-renewal of intestinal stem cells (ISCs) and transit …
WEBJan 18, 2019 · In addition to the actively cycling ISCs that maintain daily homeostasis, accumulating evidence supports the existence of other pools of stem/progenitor cells …
WEBregeneration. The Intestinal Stem Cell Niche. The epithelium of the small intestine is composed of a monolayer of different cell types that form serial arrays of luminal projections (villi) and cup-shaped invaginations (crypts).
WEBDec 11, 2013 · 30 Altmetric. Metrics. Key Points. Intestinal stem cells are responsible for the remarkable ability of the intestinal epithelium to efficiently renew and repair itself throughout life. The...
WEBMar 16, 2020 · The ability of stem cells to divide and differentiate is necessary for tissue repair and homeostasis. Appropriate spatial and temporal mechanisms are needed. …
WEBAbstract. Intestinal epithelium undergoes rapid cellular turnover, relying on the local niche, to support intestinal stem cells (ISCs) function and self-renewal. Research into the association between ISCs and disease …
Regulation of Drosophila intestinal stem cell maintenance and ...
WEBDec 17, 2014 · Here, we demonstrate that Esg plays a pivotal role in intestinal homeostasis, maintaining the stem cell pool while influencing fate decisions through …
Concise Review: The Potential Use of Intestinal Stem Cells to …
WEBSep 16, 2016 · Introduction. Intestinal failure (IF) is a rare multifactorial clinical condition that results in patients' inability to sustain normal growth and nutritional and hydration …
The Potential Role of Intestinal Stem Cells and Microbiota for the ...
WEBMay 30, 2024 · The human GI tract includes the oral cavity, pharynx, esophagus, stomach, small intestine, large intestine, and anal canal. It serves as hollow, tube-like organs that …
Muscarinic receptor M3 contributes to intestinal stem cell …
WEBJul 9, 2021 · The ability of intestinal stem cells (ISCs) to divide and differentiate is necessary for tissue repair and homeostasis. Maintenance of a functional intestine …
Stem cells in homeostasis and cancer of the gut - PubMed
WEBMar 30, 2019 · Interestingly, as opposed to the traditional stem cell theory, the ISC is not a static population but displays significant plasticity and in situations of tissue regeneration …
Q&A: Studies reveal gut's true stem cells, challenging previous …
WEB4 hours ago · The gut's stem cells were supposedly identified more than 15 years ago in a landmark study. But using new lineage tracing and computational tools, the Columbia …
Redefining intestinal stemness: The emergence of a new ISC …
WEB19 hours ago · In tissue homeostasis, intestinal stem cells (ISCs) undergo continuous self-renewal to sustain rapid cellular turnover. In this issue of Cell, Capdevila et al. and …
The Gut’s Stem Cells Get a New Identity | Columbia University …
WEB19 hours ago · The gut’s stem cells are some of the hardest-working stem cells in the body. They work continuously throughout our lives to replenish the short-lived cells that line …
Roles of intestinal epithelial cells in the maintenance of gut ...
WEBMay 26, 2017 · Introduction. The gastrointestinal tract is an organ that takes in food, digests it and absorbs food-derived nutrients. Therefore, exogenous microorganisms, such as …
Regulation of Drosophila intestinal stem cell maintenance and ...
WEBNov 28, 2014 · Escargot (Esg) is required for intestinal stem cell ( ISC) maintenance. •. Loss of Esg biases the fate of ISC s towards the enteroendocrine ( EE) lineage. •. Esg …
Modulation of stem cell fate in intestinal homeostasis, injury and ...
WEBMay 5, 2023 · Modulating the essential niche signaling or facilitating beneficial elements in the stem cell microenvironment provides novel insights into the regenerative process …
Autocrine and paracrine unpaired signaling regulate intestinal …
WEBDec 15, 2012 · Upd1 regulates intestinal stem cell maintenance. (A) Knockdown of each upd gene with the esg F/O system shows that Upd1 but not Upd2 or Upd3 is required for …
Full article: Microbial metabolite butyrate modulates granzyme B …
WEB19 hours ago · Citation 2 Among gut bacterial metabolites, short-chain fatty acids (SCFAs), the gut bacterial metabolites by fermentation of dietary fibers, have been shown to …
IDDF2021-ABS-0074 Gut microbial metabolite of tryptophan …
WEBDespite the significant association of intestinal stem cell (ISC) function with gut homeostasis, the contribution of ISCs in chronic psychological stress to disrupt the …
Biotin controls intestinal stem cell mitosis and host-microbiome ...
WEBMar 8, 2022 · Here, we study the role of the Drosophila intestinal stem cell (ISC)-specific biotin transporter Smvt in midgut homeostasis, infection-induced regeneration, and …
Microorganisms | Free Full-Text | Summatory Effects of …
WEB3 days ago · The maintenance of a chronic physiological state of low-grade metabolic acidosis produces detrimental effects on systemic health, physical performance, and …
A growth factor-free culture system underscores the coordination ...
WEBSep 4, 2018 · The successful long-term maintenance of Lgr5 + ISCs with the two small molecules CHIR and LDN provides a convenient and cheap culture system for the study …
Stem Cells in Repair of Gastrointestinal Epithelia - PMC
WEBJun 14, 2017 · Each unit can be subdivided into a villus, protruding into the gut lumen and containing differentiated cells responsible for digestion and absorption, and crypt of …
Gut Stem Cell Research Reveals Mistaken Cellular Identity
WEB19 hours ago · Read time: 4 minutes. Two independent studies by Columbia scientists suggest that research into the gut’s stem cells over the past 15 years has been marred …
Contribution of Toxin–Antitoxin Systems to Adherent-Invasive
WEB19 hours ago · Pathobionts have been implicated in various chronic diseases, including Crohn’s disease (CD), a multifactorial chronic inflammatory condition that primarily …
Metabolic regulation of somatic stem cells in vivo - Nature
WEBFeb 28, 2022 · Stem cell maintenance throughout life in many tissues depends upon minimizing anabolic pathway activation and cell division. Consequently, stem cell …
Queensland researchers target gut health to slow or stop …
WEBMay 27, 2024 · The gut is a new target The Queensland research will involve both human and animal studies to identify new classes of therapeutics to treat Parkinson's disease, …
Dendritic cells loaded with allogeneic tumour cell lysate plus best ...
WEB1 day ago · We searched PubMed and abstracts of major conferences for all clinical studies, published between Jan 1, 2019, and Dec 1, 2023, in English and Dutch, evaluating …
Vedolizumab for the prevention of intestinal acute GVHD after
WEB10 hours ago · Acute graft-versus-host disease (aGVHD) of the lower gastrointestinal (GI) tract is a major cause of morbidity and mortality in patients receiving allogeneic …
A guide to adaptive immune memory | Nature Reviews Immunology
WEB3 days ago · This Review provides a guide to the memory cells of the adaptive immune system, comprising memory T cells, memory B cells and plasma cells; it covers their …
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