A cowardly alien race known as the "Boov", led by Captain Smek, commence their "friendly" invasion on the planet Earth. Relocating the humans, whom the Boov deem as simple and backwards, to the Australian Outback, the Boov inhabit their homes. Oh, an accident-prone, free-thinking Boov, decides to invite the other Boov to his apartment for a housewarming party, but no one comes. Meanwhile, 13-year-old Gratuity "Tip" Tucci and her Japanese Bobtail cat Pig, who managed to avoid being taken during the invasion, drive around the city searching for Lucy, Tip's mom.

Oh visits grumpy Boov traffic officer Kyle, to invite him to the party. However, Oh accidentally sends the invitation email to every alien race in the galaxy, including the "Gorg". The Gorg have been the Boov's longtime enemy ever since a failed peace meeting, during which Captain Smek stole an artifact he later dubbed "The Shusher". Furious with Oh for revealing their new home to the Gorg, the Boov declare him a fugitive. Oh walks back to a pod, telling the assistant to take him to Paris, and then refuses and wants to go to Antarctica, the only place on Earth with no Boovs. The assistant refuses and initiates self-destruct for 5 seconds, and the pod had popped. Oh then runs into a store named "Just Lamps", and just as he starts walking he steps on the switches, which makes the lamps turn on. Tip sees Oh get dancing in fear. Oh attempts to run away and hide, ending up in a convenience store, just as Tip crashes the car and enters the store in search of supplies. Tip attacks Oh on sight, and locks him in a freezer, until he promises to fix her car, which he turns into a flying craft named "Slushious".

To hide from the Boov, Oh promises to help Tip find her mom, Lucy. However, he secretly plans to abandon Tip and take himself to Antarctica. He attempts to abandon Tip in a public restroom but is thwarted by Kyle, who arrives to force Oh to give him his email password so Smek can cancel the party invitation that Oh sent.

Escaping Kyle, Oh and Tip head to Paris where the Boov Command Centre, and manage to sneak in. Oh cancels the invitation before it reaches the Gorg; he then looks for Lucy, and the computer confirms she is in a human camp in Australia, where she is also looking for her daughter. Trying to return to Slushious, Oh and Tip are cornered by Smek and many other Boov at the Great Antenna (Eiffel Tower). Smek orders Oh's execution. Tip uses a Boov gravity device to turn the tower upside down, and she and Oh escape.

Oh informs Tip that he no longer believes Smek's propaganda about humans being simple and backward, and apologizes to her. They fly to Australia, but are surrounded by hundreds of Boov fleeing from Gorg drones, sent to search for them. Slushious is wrecked, but Oh finds a Gorg SuperChip in a crashed drone, and uses it to repair the car.

When they reach the human relocation camp, Oh realizes the other Boov are evacuating, and fears that the Gorg will take vengeance on Earth when they cannot find the Boov. He tries to convince Tip to flee with them, but she refuses. Oh joins the Boov, and the Gorg attacks the Boovs' mothership. Oh runs back towards the Gorg to use the SuperChip to power the Boov mothership, while t…

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• Jim Parsons as Oh, a Boov outcast.
• Rihanna as Gratuity "Tip" Tucci, a teenage girl who befriends Oh.
• Steve Martin as Captain Smek, the leader of the Boov race.
• Jennifer Lopez as Lucy Tucci, Tip's mother. This is Lopez’ first collaboration with Johnson since her previous role as Azteca in the 1998 DreamWorks film, Antz.
• Matt Jones as Kyle, a Boov police officer.
• Brian Stepanek as the Gorg Commander, the leader and father of the Gorg races.
• Frank Welker as Pig, Tip's pet Japanese Bobtail (uncredited)
Additionally, April Lawrence and Nigel W. Tierney voice Boov Announcer and Child A respectively.

In 2008, DreamWorks Animation optioned the book's rights to adapt it into an animated feature film. On his blog, Adam Rex announced that DreamWorks renewed the option of the adaptation in 2011. On June 20, 2012, it was revealed that the title of the film would be Happy Smekday!, Jim Parsons and Rihanna would star in the lead roles, and the film would be released in the fourth quarter of 2014. In September 2012, 20th Century Fox and DreamWorks Animation announced a release date of November 26, 2014. In June 2013, the film was retitled from Happy Smekday! to Home.

On October 3, 2013, it was announced that Steve Martin and Jennifer Lopez had joined the cast. On May 20, 2014, the film's release date was pushed back to March 27, 2015, switching places with DreamWorks Animation's film Penguins of Madagascar. Jeffrey Katzenberg, DreamWorks Animation's CEO, reasoned that Penguins, coming from one of DWA's most successful franchises, would more easily stand out during Thanksgiving time, while Home would try to take advantage of the less competitive spring release window, and repeat successful spring launches of some of DWA's original films, including The Croods and How to Train Your Dragon.

Pacific Data Images did production services for the film before its closure in January 2015.