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Melanogenesis is mainly regulated by MSH-α and ACTH, which originate from POMC cleavage, activate the melanocortin receptor MC1-R, and stimulate melanotropic activity. UVR is the …

Melanin pigments are responsible for human skin and hair color, and they protect the body from harmful ultraviolet light. The black and brown melanin pigments are synthesized in specialized …

Dec 11, 2024 · Background: Key cellular players regulating human skin pigmentation include melanocytes in the epidermis that synthesize melanin, neighboring keratinocytes that receive …

Jul 15, 2016 · Melanocytes are melanin-producing cells found in skin, hair follicles, eyes, inner ear, bones, heart and brain of humans. They arise from pluripotent neural crest cells and …

Melanin, which is responsible for pigmentation in the hair, skin, and dyes of humans, is synthesized by melanocytes by the process of melanogenesis. Skin pigmentation and …

NAFL has been reported to cause the longest delay in melasma relapse, whereas Q-switched lasers have the highest relapse rates ... inhibited melanogenesis and induced autophagy in …

In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular signals are transduced via dedicated signalling pathways and mostly converge to MITF, a transcription …

Dec 14, 2023 · The pigment-producing cells called melanocytes, targeted to generate melanin, give human skin its distinctive color in the epidermis, the skin's top layer. Tyrosinase, a major …

Jun 1, 2024 · Recent studies have demonstrated a diverse range of interleukins (ILs) and various inflammatory mediators that can modulate the proliferation and differentiation of human …

The process of melanin synthesis and distribution is called melanogenesis, a process that is based on melanocytes present among the basal cells of the epidermis. Pigments formed in …

In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular signals are transduced via dedicated signalling pathways and mostly converge to MITF, a transcription …

Jun 30, 2016 · Melanogenesis is a multistep process and begins with the conversion of amino acid L-tyrosine to DOPAquinone. The addition of cysteine or glutathione to DOPAquinone leads to …

Here we have described how melanogenesis in humans requires a diverse range of pathways and enzymes. These in turn require extensive regulatory mechanisms to control their function. …

Melanogenesis is a common physiological process to protect skin from solar ultraviolet light. However, excessive melanin may cause pigmentation in skin and malignant melanoma. …

The synthesis and distribution of melanin in the epidermis involves several steps: transcription of melanogenic proteins, melanosome biogenesis, sorting of melanogenic proteins into the …

This review introduces four major topics of melanogenesis cascade that include (1) melanocyte development and differentiation, (2) melanogenesis and intracellular trafficking for …

5 days ago · Background Melanin pigmentation in oocytes is a critical feature for both the esthetic and developmental aspects of oocytes, influencing their polarity and overall development. …

Melanogenesis is a complex process that corresponds to multiple genes and signals, and is closely related to multiple epigenetic mechanisms. Epigenetic changes often occur earlier than …

Melanogenesis by itself and its highly reactive intermediates show cytotoxic, genotoxic, and mutagenic activities, and it can stimulate glycolysis and hypoxia-inducible factor 1-alpha (HIF …