The chemical origin of life hypothesis suggests that life originated in a prebiotic soup with heterotrophs. The summary of this theory is as follows: early Earth had a highly reducing atmosphere and energy sources such as electrical energy in the form of lightning, which resulted in reactions that formed simple organic compounds, which further reacted to form more complex compounds and eventually resulted in life. Alternative theories of an autotrophic origin of life contradict this theory.

The theory of a chemical origin of life beginning with heterotrophic life was first proposed in 1924 by Alexander Ivanovich Oparin, and eventually published "The Origin of Life." It was independently proposed for the first time in English in 1929 by John Burdon Sanderson Haldane. While these authors agreed on the gasses present and the progression of events to a point, Oparin championed a progressive complexity of organic matter prior to the formation of cells, while Haldane had more considerations about the concept of genes as units of heredity and the possibility of light playing a role in chemical synthesis (autotrophy).

Evidence grew to support this theory in 1953, when Stanley Miller conducted an experiment in which he added gasses that were thought to be present on early Earth – water (H2O), methane (CH4), ammonia (NH3), and hydrogen (H2) – to a flask and stimulated them with electricity that resembled lightning present on early Earth. The experiment resulted in the discovery that early Earth conditions were supportive of the production of amino acids, with recent re-analyses of the data recognizing that over 40 different amino acids were produced, including several not currently used by life. This experiment heralded the beginning of the field of synthetic prebiotic chemistry, and is now known as the Miller–Urey experiment.

On early Earth, oceans and shallow waters were rich with organic molecules that could have been used by primitive heterotrophs. This method of obtaining energy was energetically favorable until organic carbon became more scarce than inorganic carbon, providing a potential evolutionary pressure to become autotrophic. Following the evolution of autotrophs, heterotrophs were able to utilize them as a food source instead of relying on the limited nutrients found in their environment. Eventually, autotrophic and heterotrophic cells were engulfed by these early heterotrophs and formed a symbiotic relationship. The endosymbiosis of autotrophic cells is suggested to have evolved into the chloroplasts while the endosymbiosis of smaller heterotrophs developed into the mitochondria, allowing the differentiation of tissues and development into multicellularity. This advancement allowed the further diversification of heterotrophs. Today, many heterotrophs and autotrophs also utilize mutualistic relationships that provide needed resources to both organisms. One example of this is the mutualism between corals and algae, where the former provides protection and necessary compounds for photosynthesis while the latter provides oxygen.

However this hypothesis is controversial as CO2 was the main carbon source at the early Earth, suggesting that early cellular life were autotrophs that relied upon inorganic substrates as an energy source and lived at alkaline hydrother…

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• Autotroph
• Heterotroph

Many heterotrophs are chemoorganoheterotrophs that use organic carbon (e.g. glucose) as their carbon source, and organic chemicals (e.g. carbohydrates, lipids, proteins) as their electron sources. Heterotrophs function as consumers in food chain: they obtain these nutrients from saprotrophic, parasitic, or holozoic nutrients. They break down complex organic compounds (e.g., carbohydrates, fats, and proteins) produced by autotrophs into simpler compounds (e.g., carbohydrates into glucose, fats into fatty acids and glycerol, and proteins into amino acids). They release the chemical energy of nutrient molecules by oxidizing carbon and hydrogen atoms from carbohydrates, lipids, and proteins to carbon dioxide and water, respectively.

They can catabolize organic compounds by respiration, fermentation, or both. Fermenting heterotrophs are either facultative or obligate anaerobes that carry out fermentation in low oxygen environments, in which the production of ATP is commonly coupled with substrate-level phosphorylation and the production of end products (e.g. alcohol, CO2, sulfide). These products can then serve as the substrates for other bacteria in the anaerobic digest, and be converted into CO2 and CH4, which is an important step for the carbon cycle for removing organic fermentation products from anaerobic environments. Heterotrophs can undergo respiration, in which ATP production is coupled with oxidative phosphorylation. This leads to the release of oxidized carbon wastes such as CO2 and reduced wastes like H2O, H2S, or N2O into the atmosphere. Heterotrophic microbes' respiration and fermentation account for a large portion of the release of CO2 into the atmosphere, making it available for autotrophs as a source of nutrient and plants as a cellulose synthesis substrate.

Respiration in heterotrophs is often accompanied by mineralization, the process of converting organic compounds to inorganic forms. When the organic nutrient source taken in by the heterotroph contains essential elements such as N, S, P in addition to C, H, and O, they are often removed first to proceed with the oxidation of organic nutrient and production of ATP via respiration. S and N in organic carbon source are transformed into H2S and NH4 through desulfurylation and deamination, respectively. Heterotrophs also allow for dephosphorylation as part of decomposition. The conversion of N and S from organic form to inorganic form is a critical part of the nitrogen and sulfur cycle. H2S formed from desulfurylation is further oxidized by lithotrophs and phototrophs while NH4 formed from deamination is further oxidized by lithotrophs to the forms available to plants. Heterotrophs' ability to mineralize essential elements is critical to plant survival.

Most opisthokonts and prokaryotes are heterotrophic; in particular, all animals and fungi are heterotrophs. Some animals, such as corals, form symbiotic relationships with autotrophs and obtain organic carbon in this way. Furthermore, some parasitic plants have also turned fully or partially heterotrophic, while carnivorous plants consume animals to augment their nitrogen supply while remaining autotrophic.

Animals are classified as heterotrophs by ingestion, fungi are classified as heterotrophs by absorption.