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- Learn more:✕This summary was generated using AI based on multiple online sources. To view the original source information, use the "Learn more" links.Cancer-related fatigue is extreme tiredness and exhaustion that doesn’t go away with rest or sleep. It can affect you physically and emotionally. It’s a very common side effect of tamoxifen and may last for weeks or months after your treatment has finished.breastcancernow.org/about-breast-cancer/treatme…Most contain diphenhydramine, which can make you feel sleepy at first but tends to disrupt the stages of sleep. Diphenhydramine can also interfere with the effectiveness of tamoxifen.www.breastcancer.org/treatment-side-effects/inso…Walsh notes that breast cancer treatment with tamoxifen or aromatase inhibitors can be another major cause of insomnia. “ [Those medications] can cause menopause-like symptoms, such as night sweats or joint pain, which interrupt sleep,” she says.www.everydayhealth.com/breast-cancer/insomnia-…
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