• This condition can be caused by tumors called gastrinomas found often on the head of the pancreas and upper small intestines. These gastrinomas secrete a hormone called gastrin.
• High levels of gastrin cause production of excess stomach acid, which leads to peptic ulcer.
• The risk factors include:
• Family history - this is likely run in families

The complications involved include:

• Abdominal perforation
• Esophageal stricture
• Bowel obstruction
• Gastrointestinal bleeding
• Gastric carcinoids
• Spread of tumor to other organs

The methods of managing this disease include medication and surgery.

Medication

Proton pump inhibitors: Used to stop acid reflux, relieve pain caused by peptic ulcers and encourage healing.

Esomeprazole . Omeprazole . Pantoprazole

Chemotherapeutic agents: Used to treat gastrinomas that cannot be removed surgically.

Streptozotocin . Doxorubicin . 5-fluorouracil

Chemotherapy: In case, if the tumor is found to be of cancerous nature, a combination of chemotherapy, targeted radiation therapy may be advised.

Streptozocin/Fluorouracil