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- Actinin is a microfilament protein. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinates contractions between sarcomeres in the horizontal axis. Alpha-actinin is a part of the spectrin superfamily.
en.wikipedia.org/wiki/Actinin - People also ask
Actinonin - Wikipedia
WebActinonin is a naturally occurring antibacterial agent that has demonstrated anti-tumor activity. [1] Actiononin has been shown to inhibit the enzyme peptide deformylase , which is essential in bacteria .
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Actinonin - an overview | ScienceDirect Topics
WebActinonin is a naturally occurring antibacterial agent [89] that was recently shown to be a potent PDF inhibitor exhibiting antibacterial activity against a wide range of different bacterial species [90]. Bacteria growing in subinhibitory concentrations of a PDF inhibitor, actinonin, release increased amounts of neutrophil-activating peptides ...
The action of actinonin: a new antimalarial drug and …
WebSep 15, 2017 · The action of actinonin: a new antimalarial drug and target. The apicomplast, a Plasmodium-specific organelle, proves to be a …
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Actinonin | C19H35N3O5 | CID 443600 - PubChem
WebUSA.gov. Actinonin | C19H35N3O5 | CID 443600 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and …
Actinomycetota - Wikipedia
The Actinomycetota (or Actinobacteria) are a diverse phylum of Gram-positive bacteria with high G+C content. They can be terrestrial or aquatic. They are of great economic importance to humans because agriculture and forests depend on their contributions to soil systems. In soil they help to decompose the organic matter of dead organisms so the molecules can be taken up anew by plants. W…
Wikipedia · Text under CC-BY-SA licenseActinin - Wikipedia
WebActinin is a microfilament protein. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinates contractions between sarcomeres in the horizontal axis. Alpha-actinin is …
Actinonin, a Naturally Occurring Antibacterial Agent, Is a Potent ...
WebAbstract. Peptide deformylase (PDF) is essential in prokaryotes and absent in mammalian cells, thus making it an attractive target for the discovery of novel antibiotics. We have identified actinonin, a naturally occurring antibacterial agent, as a potent PDF inhibitor.
The actinin family proteins: biological function and clinical ...
WebAug 25, 2015 · The alpha actinin (ACTN) family proteins are actin-bundling proteins that are evolutionarily conserved and possess several functional domains. Vertebrates including humans express four unique actinin genes that display distinct expression patterns and biochemical properties.
Actinonin and Analogs: Inhibitors of Bacterial Peptide ... - Springer
WebJan 1, 2013 · More than 30 years later the antibacterial activity of actinonin was attributed to inhibition of the metallohydrolase... Actinonin and Analogs: Inhibitors of Bacterial Peptide Deformylase | SpringerLink
Actinonin, a meprin A inhibitor, protects the renal microcirculation ...
WebINTRODUCTION. Sepsis is a disorder initiated by excessive activation of innate immunity. It is a serious medical problem particularly in patients in the intensive care unit (ICU) 1 where it is the second leading cause of death in non-coronary ICU patients ( 1, 2 ).
The discovery of actin: “to see what everyone else has seen, and …
WebMay 15, 2019 · Actin is among the most highly abundant and ubiquitous proteins in eukaryotic cells. The structure, dynamics and functional diversity of actin have continued to mesmerise cell and molecular biologists, biophysicists and physiologists for more than three quarters of a century. The discovery and initial characterization of actin, which took place …
Actinonin - Wikiwand
WebActinonin is a naturally occurring antibacterial agent that has demonstrated anti-tumor activity.
Actinonin - an overview | ScienceDirect Topics
WebActinonin. Actinonin, amastatin and bestatin inhibit Manduca sexta aminopeptidase N1 (MsAPN1) activity, as do the Zn2+ chelating agents 2,2′-dipyridyl and 1,10-phenanthroline [3]. From: Handbook of Proteolytic Enzymes (Third Edition), 2013. Related terms: Alanine Aminopeptidase; Natural Product; Nicotinamide Nucleotide; Phosphotransferase ...
Actinonin, a naturally occurring antibacterial agent, is a potent ...
WebFeb 15, 2000 · Peptide deformylase (PDF) is essential in prokaryotes and absent in mammalian cells, thus making it an attractive target for the discovery of novel antibiotics. We have identified actinonin, a naturally occurring antibacterial agent, as …
Characterization of the Actinonin Biosynthetic Gene …
WebMar 30, 2018 · Owing to its antimicrobial activity, actinonin has served as a lead compound for the development of new antibiotic drug candidates. Recently, we identified a putative gene cluster for the biosynthesis of …
Actinonin, a naturally occurring antibacterial agent, is a potent ...
WebFeb 15, 2000 · Peptide deformylase (PDF) is essential in prokaryotes and absent in mammalian cells, thus making it an attractive target for the discovery of novel antibiotics. We have identified actinonin, a naturally occurring antibacterial agent, as …
Characterization and evaluation of antimicrobial activity of …
WebSep 6, 2017 · Actinonin is a natural pseudo-peptides in the acidic component produced by a strain of Streptomyces spp. and Actinomyces spp. isolated from soil . It has been reported that actinonin inhibits human peptide deformylase (Homo sapiens PDF, or HsPDF), which is a functional enzyme in mitochondria required for growth of normal or cancer cells ...
The actinin family of actin cross-linking proteins – a genetic ...
WebAug 25, 2015 · Actinins are one of the major actin cross-linking proteins found in virtually all cell types and are the ancestral proteins of a larger family that includes spectrin, dystrophin and utrophin. Invertebrates have a single actinin …
Actinide - Wikipedia
WebThe actinide (/ ˈ æ k t ɪ n aɪ d /) or actinoid (/ ˈ æ k t ɪ n ɔɪ d /) series encompasses at least the 14 metallic chemical elements in the 5f series, with atomic numbers from 89 to 102, actinium through nobelium. (Number 103, lawrencium, is sometimes also included despite being part of the 6d transition series.)The actinide series derives its name from the first …
Structures of actinonin-bound peptide deformylases from
WebSep 22, 2014 · Actinonin, a naturally occurring, highly potent inhibitor, is bound tightly at the active site. The conformation of actinonin in the Ef PDF and Spy PDF complexes was similar to those of all others. The detailed information from this study will facilitate the development of novel antibacterial molecules. References.
JCI - Human mitochondrial peptide deformylase, a new …
WebOct 15, 2004 · We show that actinonin, a peptidomimetic antibiotic that inhibits HsPDF, also inhibits the proliferation of 16 human cancer cell lines. We designed and synthesized 33 chemical analogs of actinonin; all of the molecules with potent activity against HsPDF also inhibited tumor cell growth, and vice versa, confirming target specificity.
Frontiers | The Inhibition and Resistance Mechanisms of …
WebSep 12, 2016 · Actinonin was reported in 1962 (Gordon et al., 1962) and was the first characterized PDF inhibitor (Chen et al., 2000). Up to now, resistance to actinonin has been reported in Staphylococcus aureus, Streptococcus pneumonia, Bacillus subtilis, Haemophilus influenza, Streptococcus pyogenes and Escherichia coli. Mechanisms …
Characterization of the Actinonin Biosynthetic Gene Cluster
WebOwing to its antimicrobial activity, actinonin has served as a lead compound for the development of new antibiotic drug candidates. Recently, we identified a putative gene cluster for the biosynthesis of actinonin. Here, we confirm and characterize this cluster by heterologous pathway expression and gene-deletion experiments.
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