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- Studies of bevirimat
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See all on WikipediaBevirimat (research code MPC-4326) is an anti-HIV drug derived from a betulinic acid-like compound, first isolated from Syzygium claviflorum, a Chinese herb. It is believed to inhibit HIV by a novel mechanism, so-called maturation inhibition. It is not currently U.S. Food and Drug Administration (FDA) … See more
According to the only currently available study, "the mean terminal elimination half-life of bevirimat ranged from 56.3 to 69.5 hours, and the mean clearance ranged from 173.9… See more
It has been found that bevirimat does not inhibit the cytochrome P450 system or interact with the human P-glycoprotein. Unformulated bevirimat is not well absorbed from the … See more
In vitro studies have shown that presence of a number of single nucleotide polymorphisms in the CA/SP1 cleavage site have resulted … See more
In December 2007, some results of the Phase IIb trial were released. Thomson Financial News reported that, "some patients respond 'very well' to the drug, while another… See more
Like protease inhibitors, bevirimat and other maturation inhibitors interfere with protease processing of newly translated HIV polyprotein precursor, called gag. Gag is an essential … See more
Preclinical studies have not presented any sign that bevirimat might be associated with any specific safety concerns that would limit its clinical use. In vitro preclinical… See more
Wikipedia text under CC-BY-SA license WEBMar 19, 2008 · Generic Name. Bevirimat. DrugBank Accession Number. DB06581. Background. Bevirimat, also known as PA-457 or YK-FH312, is investigated in clinical …
WEBAbstract. Existing antiretroviral treatments for HIV type-1 (HIV-1) disease are limited by problems of resistance and drug-drug interactions. Bevirimat is a novel HIV-1 …
- Author: David E Martin, Karl Salzwedel, Graham P Allaway
- Publish Year: 2008
WEBMar 3, 2019 · A betulinic acid-based compound, bevirimat (BVM), inhibits HIV-1 maturation by blocking a late step in protease-mediated Gag processing: the cleavage of the capsid …
- Author: Emiko Urano, Uddhav Timilsina, Justin A. Kaplan, Sherimay Ablan, Dibya Ghimire, Phuong Pham, Nishani...
- DOI: 10.1128/JVI.02017-18
- Publish Year: 2019
- Publication: J Virol. 2019 Mar 15; 93(6): e02017-18.
WEBBevirimat represents a new class of HIV drugs called maturation inhibitors and its novel mechanism of action offers potential for use either alone or in combination with current …
WEBDec 12, 2018 · MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat - PMC. Journal List. Proc Natl Acad Sci U S A. v.115 …
WEBNov 24, 2010 · Bevirimat (BVM) defines a new class of antiviral drugs termed maturation inhibitors. BVM acts by blocking the final cleavage event in Gag processing, the …
WEBBevirimat [3-O- (3',3'-dimethylsuccinyl)betulinic acid] is the first in a new class of anti-human immunodeficiency virus (HIV) drugs that inhibit viral maturation by specifically …
WEBBevirimat (PA-457, 69), extracted from a Chinese herb Syzygium claviflorum is under Phase IIb trial in combination therapy by Panacos [121b]. Bevirimat is believed to inhibit …
WEBJun 1, 2008 · More. Abstract. Existing antiretroviral treatments for HIV type-1 (HIV-1) disease are limited by problems of resistance and drug-drug interactions. Bevirimat is a …
Bevirimat - an overview | ScienceDirect Topics
WEBWith the advent of Bevirimat (a succinic acid hemiester derivative of betulinic acid) as a potent anti-HIV agent with a new mechanism of action (maturation inhibition), significant …
Multiple-dose pharmacokinetics and safety of bevirimat, a novel ...
WEBBackground and objective: Bevirimat [3-O- (3',3'-dimethylsuccinyl)-betulinic acid] is a novel inhibitor of HIV-1 maturation. This study was performed to investigate the …
Potent Activity of the HIV-1 Maturation Inhibitor Bevirimat in SCID …
WEBNov 28, 2007 · The HIV-1 maturation inhibitor, 3- O - (3′,3′-dimethylsuccinyl) betulinic acid (bevirimat, PA-457) is a promising drug candidate with 10 nM in vitro antiviral activity …
WEBExisting antiretroviral treatments for HIV type-1 (HIV-1) disease are limited by problems of resistance and drug–drug interactions. Bevirimat is a novel HIV-1 maturation inhibitor …
Alkyl Amine Bevirimat Derivatives Are Potent and Broadly
WEBOct 19, 2015 · PMCID: PMC4704169. DOI: 10.1128/AAC.02121-15. Abstract. Concomitant with the release of human immunodeficiency virus type 1 (HIV-1) particles from the …
Repurposing of HIV/HCV protease inhibitors against SARS-CoV …
WEBSep 23, 2022 · Bevirimat: 174022-42-5: HIV Protease inhibitor: Nelfinavir: 159989-64-7: HIV Protease inhibitor: Paritaprevir: 1221573-85-8: HCV Protease inhibitor: HZ1157: …
Bevirimat | C36H56O6 | CID 457928 - PubChem
WEBBevirimat | C36H56O6 | CID 457928 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity …
New Betulinic Acid Derivatives for Bevirimat-Resistant Human ...
WEBBevirimat (1, BVM) is an anti-HIV agent that blocks HIV-1 replication by interfering with HIV-1 Gag-SP1 processing at a late stage of viral maturation. However, clinical trials of 1 …
MicroED for the study of protein–ligand interactions and the
WEBOct 27, 2021 · The drug bevirimat is an inhibitor of HIV maturation and acts on the HIV Gag capsid protein by binding to it and preventing protease cleavage 27. The detailed …
New Phosphorus Analogs of Bevirimat: Synthesis, Evaluation of …
WEBOct 21, 2019 · Since the beginning of the human immunodeficiency virus (HIV) epidemic, many groups of drugs characterized by diverse mechanisms of action have been …
The prototype HIV-1 maturation inhibitor, bevirimat, binds to the …
WEBDec 7, 2011 · Bevirimat (BVM), previously called DSB [ 3 ], PA-457 [ 4 ], or YK-FH312 [ 5] potently inhibits HIV-1 replication in tissue culture and is efficacious in HIV-1 infected …
Bevirimat (PA-457) | HIV Inhibitor | MedChemExpress
WEBBevirimat (PA-457; MPC-4326; YK FH312) is an anti-HIV agent derived from a betulinic acid-like compound; is believed to inhibit HIV by a novel mechanism, so-called …
The prototype HIV-1 maturation inhibitor, bevirimat, binds to the …
WEBDec 7, 2011 · PMID: 22151792. PMCID: PMC3267693. DOI: 10.1186/1742-4690-8-101. Abstract. Background: Bevirimat, the prototype Human Immunodeficiency Virus type 1 …
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