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  2. Engorgement of the mesenteric vessels

    Comb sign is the engorgement of the mesenteric vessels with vascular dilatation, tortuosity with spacing of the vasa recta, and prominence of surrounding mesenteric fat resembling a comb and is associated with Crohn’s disease.
    Author: Charlotte Knox, John Almeida
    Publish Year: 2021
    www.cghjournal.org/article/S1542-3565(20)30918-6/fulltext
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    What is comb sign in Crohn's disease?The Comb Sign in Crohn’s Disease comb sign, characterized by engorgement of the mesenteric vessels with vascular dilatation, tortuosity with spacing of the vasa recta, and prominence of surrounding mesenteric fat resemble, which is commonly associated with Crohn’s disease.
    What is a comb sign?CT of the abdomen with contrast revealed multiple linear and tortuous opacities on mesenteric side of affected bowel, which is also known as ‘comb sign’, along with thickening and enhancement of the jejunal mucosa ( Figure 1 ). Thickening and enhancing mucosa with loss of haustration in descending colon is also found (not shown).
    Does a comb sign indicate inflammatory bowel disease?Although no gastrointestinal symptoms were reported, the comb sign led to the suspicion of inflammatory bowel disease. Colonoscopy was performed, and histopathological examination revealed findings consistent with Crohn's disease. Mesalazine and budesonide were prescribed.
    What does a comb sign mean on a CT scan?The presence of the comb sign suggests an acute exacerbation of Crohn’s disease. 37 Target sign The “target sign” represents an enhancement pattern of the bowel wall seen in various disease processes on contrast-enhanced CT or MRI scans.
     
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