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- The main difference between liposomes and niosomes is that liposomes are made up of phospholipids, which contain two hydrophobic tails whereas niosomes are made up of non-ionic surfactants, which usually contain a single hydrophobic tail. Furthermore, liposomes may or may not contain cholesterol while niosomes contain cholesterol.pediaa.com/what-is-the-difference-between-liposomes-and-niosomes/
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