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  2. Compliance can be calculated as both a continuous and dichotomous measure. As a continuous measure, the most common methods, as outlined and proposed by the ISPOR working group, are by way of medication possession ratio (MPR) and proportion of days covered (PDC). MPR is the ratio of days medication supplied to days in an time interval (Steiner).
    www.pharmasug.org/download/sde/sd2016/Pharm…
    There are numerous methods for calculating adherence; however, researchers favor the use of the Medication Possession Ratio (MPR) or the Proportion of Days Covered (PDC). Generally, MPR measures adherence by comparing the days of medication supply to the number of days in a time interval (Steiner, 1997).
    support.sas.com/resources/papers/proceedings13/…
    The PDC looks at the proportion of days in which the person has access to the medication, over the POI and is generally calculated as: (sum of days covered in the POI) ÷  (number of days in the POI) × 100 [ 15 ]. Typically, the threshold for adequate adherence has been placed at 80% for most medications, and 90% for antiretrovirals [ 1, 18 ].
    joppp.biomedcentral.com/articles/10.1186/s40545-0…
    Counting the number of pills remaining in a patient's supply and calculating the number of pills that the patient has taken since filling the prescription is the easiest method for calculating patient medication adherence.
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    How do you calculate patient medication adherence?Counting the number of pills remaining in a patient's supply and calculating the number of pills that the patient has taken since filling the prescription is the easiest method for calculating patient medication adherence. Some data indicate that this technique may underestimate adherence in older populations (Grymonpre et al. 1998).
    What metrics are used to calculate medication adherence?For retrospective studies, this review discusses metrics designed to calculate medication adherence based on fills or dispense dates and days supplied. Such metrics include medication possession ratio (MPR) and proportion of days covered (PDC).
    How do you estimate adherence from a pharmacy database?Two methods for estimating adherence from pharmacy databases are commonly used [ 13, 14, 15 ]. These are the medication possession ratio (MPR) and the proportion of days covered (PDC).
    How do I choose the best medication adherence measure?Selecting an adherence measure requires careful consideration. There is no one best measure of medication adherence. Ideally, how one measures adherence should help inform how best to address the challenges of non-adherence. 6. Practice Implications
     
  4. Studies of how to calculate medication adherence
  5. Understanding Adherence Measure Calculations

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      WEBFeb 24, 2023 · For retrospective studies, this review discusses metrics designed to calculate medication adherence based on fills or dispense dates and days supplied. Such metrics include medication possession …

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