identifying the effects of interrupting the cell cycle when the cell cycle is interrupted what is the end result tumors new cells mutations - Search
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  2. Generally, mutations of two types of cell cycle regulators can promote the development of cancer: Positive regulators, which normally promote cell growth, may become hyperactivated (oncogenic). Negative regulators (tumor suppressors), which prevent the formation of tumors, may become inactivated.
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    How does the cell cycle affect cancer growth?The cell cycle plays a crucial role in maintaining homeostasis during the replication of DNA and the division of cells. Any mutation inside specific genes can disrupt this balance, leading to cancer growth.
    How do mutations in cancer cells affect cell cycle control?Mutations in cancer cells, shown in red, primarily affect cell cycle control in response to DNA damage and growth signals during the pre-S phase. These mutations drive S phase entry and prevent cell cycle exit.
    Why does cancer develop as a multi-step process?Cells have many different mechanisms to restrict cell division, repair DNA damage, and prevent the development of cancer. It’s thought that cancer develops in a multi-step process, in which multiple mechanisms must fail before a critical mass is reached and cells become cancerous.
    Can mutations initiate cell cycle entry?Patients with mutations that initiate cell cycle entry are likely to benefit 180. Adjustment of treatments on the basis of additional genotypes is currently being tested, and phase II trials have started for triple-negative breast cancer, small-cell lung cancer, platinum-resistant ovarian cancer and haematological cancers 181.
     
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