How to prune Pothos houseplants: Start by locating damaged, discolored, dead, and dying leaves. Using sterile pruners, cut them off the stem just below a healthy leaf node. Then, take care of any overgrown sections, shaping the plant to your liking.

There are two types of pruning that you may opt to do when growing pothos. The first is to encourage branching. If you snip a vine right next to a node, it will send out new growth, usually in the form of multiple branches. You can do this to any branch of any length. The other type of pruning is to remove length.