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- Studies of factor xi activity low at 46%
Factor XI deficiency in humans - Journal of Thrombosis and …
WEBFactor XI (FXI) deficiency is an autosomal recessive injury-related bleeding tendency, which is common in Jews particularly of Ashkenazi origin. To date, 152 mutations in the FXI gene have been reported with four exhibiting founder effects in specific populations, …
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Inhibition of factor XI activation attenuates inflammation and ...
WEBMay 17, 2012 · Because activation of the contact proteases factor XII (FXII), prekallikrein, and factor XI (FXI) can trigger coagulation and inflammatory responses, the contact …
- Author: Erik I. Tucker, Norah G. Verbout, Philberta Y. Leung, Sawan Hurst, Owen J. T. McCarty, David Gailani...
- Publish Year: 2012
WEBFactor XI (FXI) deficiency is an autosomal reces-sive injury-related bleeding tendency, which is common in Jews particularly of Ashkenazi origin.
Pharmacological targeting of coagulation factor XI mitigates the ...
WEBHuman coagulation factor (F) XI deficiency, a defect of the contact activation system, protects against venous thrombosis, stroke, and heart attack, whereas FXII, plasma …
Eighteen unrelated patients with factor XI deficiency, four novel ...
WEBApr 28, 2003 · Factor XI (FXI) deficiency is an autosomal bleeding disorder of variable severity. Inheritance is not completely recessive as heterozygotes may display a distinct, …
Factor XI: Hemostasis, Thrombosis, and Antithrombosis
WEBMay 1, 2012 · Recent studies have provided new insight into the molecular structure and functional features of FXI and have demonstrated distinct structural and biological …
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Clinical Pharmacology of Factor XI Inhibitors: New Therapeutic ...
WEBOct 26, 2022 · The fact that factor (F)XI deficiency is associated with a mild bleeding phenotype and that FXI knockdown or inhibition in different animal models reduced the …
Clinical Pharmacology of Factor XI Inhibitors: New …
WEBOct 26, 2022 · The inhibitory effect of fesomersen on FXI activity, observed at day 85, was equal to 56.0% in the 200 mg group and 70.7% in the 300 mg group compared to basal ( Figure 8) [ 38 ]. Similar reductions were …
Detection of Mild Clotting Factor Deficiencies. Critical Role of the ...
WEBDec 3, 2015 · To investigate the suitability of 5 commercially available aPTT reagents to detect mild/moderate deficiencies of clotting factors, we assessed their responsiveness …
Persistently High Levels of Coagulation Factor XI as a Risk …
WEBJul 25, 2023 · Factor XI deficiency—also known as haemophilia C—is an autosomal recessive disorder that is most commonly found in the Ashkenazi Jewish population and …
Combined Coagulation Factor XI and Factor XII Deficiency in An ...
WEBNov 16, 2008 · Is to be noted that the patient has never had a documented thromboembolic episode or excessive bleeding, despite the exposure, respectively, to estrogen …
Factor XI Inhibitors: perspectives in primary and secondary
WEBMay 14, 2024 · Factor XI as a new target for prevention of thromboembolism in cardiovascular disease: a meta-analysis of randomized controlled trials. Article 18 May …
Turning Up to Eleven: Factor XI Inhibitors as Novel
WEBMar 1, 2021 · Factor XI (FXI) has garnered attention as a potential drug target based on observations in patients with inherited FXI deficiency or as a biomarker in the general …
Safety of the oral factor XIa inhibitor asundexian compared with ...
WEBApr 3, 2022 · Summary. Background. Direct-acting oral anticoagulant use for stroke prevention in atrial fibrillation is limited by bleeding concerns. Asundexian, a novel, oral …
Factor XI deficiency in humans - ScienceDirect
WEBJul 1, 2009 · Factor XI (FXI) deficiency is an autosomal recessive injury-related bleeding tendency, which is common in Jews particularly of Ashkenazi origin.
Pharmacological targeting of coagulation factor XI mitigates the ...
WEBApr 1, 2021 · Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low‐density lipoprotein receptor‐deficient mice - …
Eighteen unrelated patients with factor XI deficiency, …
WEBCongenital Factor XI (FXI) deficiency shows a high variability in clinical phenotype. To date, many allele variants have been shown to cause this bleeding disorder. However, the genotype-phenotype relationship is …
The Evolving Dilemma of Factor XI in Pregnancy: Suggestions
WEBJan 29, 2018 · Abstract. A case of a patient with severe factor XI (FXI) deficiency who presented for her seventh labor and delivery is presented. The nature of FXI deficiency, …
Inhibition of factor XI activation attenuates inflammation and ...
WEBMay 5, 2012 · Activation of the contact protease factor XII (FXII) on negatively charged surfaces, including bacterial components, activates prekallikrein and factor XI (FXI) in …
Factor XI Inhibitors: Potential Role in End-Stage Kidney Disease
WEBNov 1, 2023 · This review article presents the most recent pharmacological data with FXI inhibitors, briefly describes phase 2 and 3 clinical trials with these agents, and critically …
Factor XI deficiency in humans - SELIGSOHN - 2009 - Journal of ...
WEBJul 13, 2009 · Factor XI (FXI) deficiency is an autosomal recessive injury-related bleeding tendency, which is common in Jews particularly of Ashkenazi origin.
Safety of the oral factor XIa inhibitor asundexian compared with ...
WEBApr 9, 2022 · Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, …
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