ttaggg sequence and inflammation - Search

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Studies of ttaggg sequence and inflammation
National Center for Biotechnology Information
Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses
Gene therapy holds exciting promise for treating many genetic disorders, but host immune responses pose a major challenge for in vivo gene transfer (1). Whereas adeno-associated viral (AAV) vectors are known to be less immunogenic than other viral vectors
Author: Ying Kai Chan…
Published: 2021/02/02
DOI: 10.1126/scitranslm…
PubMed
A suppressive oligodeoxynucleotide expressing TTAGGG motifs modulates cellular energetics through the mTOR signaling pathway
Immune-mediated inflammation must be down-regulated to facilitate tissue remodeling during homeostatic restoration of an inflammatory response. Uncontrolled or over-exuberant immune activation can cause autoimmune diseases, as well as tissue destruction.
Author: Volkan Yazar
Published: 2020/01/09
Keywords: A151 ODN…
National Center for Biotechnology Information
A suppressive oligodeoxynucleotide expressing TTAGGG motifs modulates cellular energetics through the mTOR signaling pathway
The immunosuppressive ODN A151 profoundly affects mTOR signaling Keywords: A151 ODN, immunometabolism, immunosuppression, microarray
Author: Volkan Yazar, …
Published: 2020/01
Publication: Int Immun…
National Center for Biotechnology Information
Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive TTAGGG Motifs Inhibit AIM2 Inflammasome Activation
Synthetic oligodeoxynucleotides comprised of the immunosuppressive motif TTAGGG block TLR9 signaling, prevent STAT1 and STAT4 phosphorylation and attenuate a variety of inflammatory responses in vivo. Here, we demonstrate that such suppressive oligodeoxynucleotides
Author: John J. Kamin…
Published: 2013/10/10
DOI: 10.4049/jimmunol.…
ScienceDirect
Invited review Structure, mechanism and therapeutic utility of immunosuppressive oligonucleotides
Synthetic oligodeoxynucleotides that can down-regulate cellular elements of the immune system have been developed and are being widely studied in preclinical models. These agents vary in sequence, mechanism of action, and cellular target(s) but share
Published: 2016/03/01
Cited By: 26
Page Count: 10
PubMed
Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes
Type I interferon (IFN) is a critical mediator of autoimmune diseases such as systemic lupus erythematosus (SLE) and Aicardi-Goutières Syndrome (AGS). The recently discovered cyclic-GMP-AMP (cGAMP) synthase (cGAS) induces the production of type I IFN
Author: Folkert Steinh…
Published: 2018/4
Keywords: Autoimmun…
National Center for Biotechnology Information
Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes
The recognition of microbial DNA is a major mechanism by which the immune system detects pathogens. Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that activates innate immune responses through production of the second messenger cGAMP,
Author: Folkert Steinh…
Published: 2018/04
DOI: 10.1002/eji.20174…
National Center for Biotechnology Information
Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats
The immune system plays a fundamental role in both the development and pathobiology of stroke. Inflammasomes are multiprotein complexes that have come to be recognized as critical players in the inflammation that ultimately contributes to stroke severity.
Author: Jing Zhao, Yo…
Published: 2015
Publication: PLoS On…
PubMed
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
A highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library. Quantitative hybridization to chromosomes sorted by flow cytometry indicates that comparable amounts of this sequence are present
Author: R K Moyzis
Published: 1988/9
Keywords: National In…
National Center for Biotechnology Information
Conservation of the human telomere sequence (TTAGGG)n among vertebrates.
To determine the evolutionary origin of the human telomere sequence (TTAGGG)n, biotinylated oligodeoxynucleotides of this sequence were hybridized to metaphase spreads from 91 different species, including representative orders of bony fish, reptiles,
Author: J Meyne, R L …
Published: 1989/09
Publication: Proc Natl …
Nature
https://www.nature.com/articles/s41467-024-49072-9
A persistent variant telomere sequence in a human pedigree
Web1 day ago · The telomere sequence is ancient. TTAGGG, the vertebrate telomeric sequence, has been conserved for at least 400 million years 1, and is restricted by the sequence-specific binding of shelterin 2 ...
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- The human TTAGGG repea…
  Original Article. Published: 22 March 2011. The human TTAGGG repeat factors 1 …
- Physical mapping of rDNA g…
  Physical mapping of rDNA genes, ( TTAGGG )n telomeric sequence and …
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National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409505
Engineering adeno-associated viral vectors to evade innate …
WebFeb 2, 2021 · To engineer scAAV.FIX, sequences were inserted into the unique KpnI site found immediately 5’ of the transthyretin promoter. 3 copies of ODN TTAGGG …
- Author: Ying Kai Chan, Ying Kai Chan, Sean K. Wang, Colin J. Chu, David A. Copland, Alexander J. Letizia, Al...
- DOI: 10.1126/scitranslmed.abd3438
- Publish Year: 2021
- Published: 2021/02/02
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Engineering adeno-associated virus vectors for gene therapy
nature.com
Adeno-associated virus vector as a platform for gene …
nature.com
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PubMed
https://pubmed.ncbi.nlm.nih.gov/31633763
A suppressive oligodeoxynucleotide expressing TTAGGG motifs …
WebJan 9, 2020 · A151, the archetypal example of a chemically synthesized suppressive oligodeoxynucleotide (ODN) based on repetitive telomere-derived TTAGGG sequences, …
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Immune System
Odn A151
Publish Year:2020
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185194
A suppressive oligodeoxynucleotide expressing TTAGGG motifs …
WebOct 21, 2019 · A151, the archetypal example of a chemically synthesized suppressive oligodeoxynucleotide (ODN) based on repetitive telomere-derived TTAGGG …
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Publish Year:2020
Odn A151
10.1093/intimm/dxz059
Science | AAAS
https://www.science.org/doi/pdf/10.1126/...
[PDF]
GENE THERAPY Engineering adeno-associated viral …
Weband TTAGGG only inhibited ~35% of induced NF- B response (fig. S1D). Thus, incorporation of a TLR9i sequence within the same molecule as an inflammatory DNA sequence …
Tags:
Viral Vectors
Inflammation
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878640
Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive …
WebOct 1, 2013 · Importantly, certain DNA sequences such as the TTAGGG repeat commonly found in mammalian telomeric DNA can serve to suppress innate immune activation. The …
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Publish Year:2013
10.4049/jimmunol.1300530
Published:2013/10/10
People also ask
Do TTAGGG proteins bind to nontelomeric DNA sequences?However, very little is known on the binding of these proteins to nontelomeric DNA sequences. The TTAGGG DNA repeat proteins 1 and 2 (TRF1 and TRF2) bind to mammalian telomeres as part of the shelterin complex and are essential for maintaining chromosome end stability.
The human TTAGGG repeat factors 1 and 2 bind to a subset of ... - Natu…
nature.com
What causes elevated TTG?
Dr. Howard E. LeWine
M.D. Chief Medical Editor, Harvard Health Publishing · 40 years of exp
An elevated blood level of TTG (tissue transglutaminase) supports a diagnosis of celiac disease. Celiac disease (also called gluten-sensitive enteropathy) is an intestinal disorder in which the body cannot tolerate gluten. Gluten is a natural protein in many grains, including wheat, barley, rye and oats. People with celiac disease have an immune reaction that is triggered by gluten. The immune reaction causes inflammation at the surface of the small intestine where it damages the surface of the intestine. When they are damaged, the intestine cannot absorb nutrients properly.
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microsoftstart.msn.com
Does TTAGGG suppress CpG-induced TLR9 phosphorylation?Data are presented as mean ± SD from three biological replicates representative of three experiments. Previous studies have shown that the deoxyguanosine residues found within A151’s TTAGGG motif play a role in suppression of CpG-induced TLR9 signaling as well as STAT1 and STAT4 phosphorylation.
Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive TTAGGG
ncbi.nlm.nih.gov
What does TTAGGG stand for?A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. A highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library.
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at th…
pnas.org
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Science | AAAS
https://www.science.org/doi/10.1126/scitranslmed.abd3438
Engineering adeno-associated viral vectors to evade innate
WebTo engineer scAAV.FIX, sequences were inserted into the unique Kpn I site found immediately 5′ of the transthyretin promoter. Three copies of ODN TTAGGG …
Tags:
Viral Vectors
Publish Year:2021
Adenovirus Vector Production Titer
American Association of Immunologists
https://journals.aai.org/jimmunol/article/…
Synthetic Oligodeoxynucleotides Containing …
WebOct 1, 2013 · Synthetic oligodeoxynucleotides (ODNs) comprised of the immunosuppressive motif TTAGGG block TLR9 signaling, prevent STAT1 and STAT4 phosphorylation and attenuate a variety of inflammatory …
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TTAGGG
TLR9
ScienceDirect
https://www.sciencedirect.com/science/article/abs/...
Structure, mechanism and therapeutic utility of …
WebMar 1, 2016 · Synthetic oligodeoxynucleotides that can down-regulate cellular elements of the immune system have been developed and are being widely studied in preclinical …
Tags:
Immune System
Publish Year:2016
PubMed
https://pubmed.ncbi.nlm.nih.gov/29215161
Suppressive oligodeoxynucleotides containing TTAGGG motifs …
WebSuppressive oligodeoxynucleotides (ODN) containing repetitive TTAGGG motifs present in mammalian telomeres have proven useful in the treatment of autoimmune diseases …
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Publish Year:2018
Nature
https://www.nature.com/articles/s41419-023-06140-0
Inhibition of cGAS–STING pathway alleviates ... - Nature
WebSep 19, 2023 · Article. Open access. Published: 19 September 2023. Inhibition of cGAS–STING pathway alleviates neuroinflammation-induced retinal ganglion cell …
PNAS
https://www.pnas.org/doi/10.1073/pnas.85.18.6622
A highly conserved repetitive DNA sequence, (TTAGGG)n, …
WebA highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library. Quantitative hybridization to chromosomes …
Tags:
Conserved Dna Sequence
Highly Repetitive Sequence
Repetitive DNA
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386451
Suppressive oligodeoxynucleotides containing TTAGGG motifs …
WebSuppressive oligodeoxynucleotides (ODN) containing repetitive TTAGGG motifs present in mammalian telomeres have proven useful in the treatment of autoimmune diseases …
Tags:
Publish Year:2018
Published:2018/04
UCL Discovery
https://discovery.ucl.ac.uk/id/eprint/10121916/31/Dick_Main Text Final.pdf
[PDF]
Engineering adeno-associated viral vectors to evade innate …
WebTLR9i sequences have been tested extensively in the literature as a standalone agent co-administered with inflammatory DNA ligands, but this strategy likely requires a large …
Tags:
Viral Vectors
TLR9
springeropen.com
https://jmhg.springeropen.com/articles/10.1186/s43042-022-00335-4
Telomere attrition and inflammation: the chicken and the egg …
WebOpen access. Published: 28 August 2022. Telomere attrition and inflammation: the chicken and the egg story. J. P. Shirley Niveta, M. Anup Kumar & Venkatachalam …
MDPI
https://www.mdpi.com/1422-0067/22/2/590
IJMS | Free Full-Text | Molecular Aspects of Senescence and
WebNov 30, 2020 · Senescence is a process characterised by a stable proliferative arrest. Sometimes it can be beneficial—for example, it can suppress tumour development or …
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Publish Year:2021
Natalia Sławińska, Renata Krupa
Oxford Academic
https://academic.oup.com/jhered/article/93/4/282/2187315
Conservation of (TTAGG)n Telomeric Sequences Among Ants …
WebJul 1, 2002 · PDF. Split View. Cite. Permissions. Share. Abstract. To determine the telomere sequence in Tapinoma nigerrimum, we carried out in situ hybridization using TTAGGG …
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- inflammation
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- inflammation
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P. Lorite, J. A. Carrillo, T. Palomeque
Publish Year:2002
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608557
Synthetic Oligodeoxynucleotides Containing Multiple Telemeric …
WebOct 16, 2015 · Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and …
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Publish Year:2015
10.1371/journal.pone.0140772
Published:2015
Nature
https://www.nature.com/articles/cr201140.pdf
[PDF]
The human TTAGGG repeat factors 1 and 2 bind to a subset …
Webto the long-range organization of chromosomes and gene regulation networks by binding to extratelomeric sequences. Keywords: telomere; TRF1; TRF2; interstitial telomeric …
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- inflammation
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- inflammation
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Publish Year:2011
TTAGGG Repeat Factors
PNAS
https://www.pnas.org/doi/10.1073/pnas.86.18.7049
Conservation of the human telomere sequence (TTAGGG)n …
WebAbstract. To determine the evolutionary origin of the human telomere sequence (TTAGGG)n, biotinylated oligodeoxynucleotides of this sequence were hybridized to …
PubMed
https://pubmed.ncbi.nlm.nih.gov/3413114
A highly conserved repetitive DNA sequence, (TTAGGG)n, …
WebA highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library. Quantitative hybridization to chromosomes …
Missing:
- inflammation
Must include:
- inflammation
Tags:
Human Telomere Ttaggg
Conserved Dna Sequence
Repetitive DNA
Cell Communication and Signaling
https://biosignaling.biomedcentral.com/articles/10...
Molecular mechanisms of aging and anti-aging strategies
WebMay 24, 2024 · The continuous accumulation of DNA-damaged cells triggers cell death and senescence, ultimately leading to chronic inflammation, loss of function, atrophy, and …
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Inflammation
DNA
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC297991
Conservation of the human telomere sequence (TTAGGG)n …
WebThe conservation of the (TTAGGG)n sequence and its telomeric location, in species thought to share a common ancestor over 400 million years ago, strongly suggest that …
Missing:
- inflammation
Must include:
- inflammation
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Human Telomere Ttaggg
Publish Year:1989
10.1073/pnas.86.18.7049
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