ttaggg sequence and inflammation - Search
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  1. Bokep

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  2. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409505

    Engineering adeno-associated viral vectors to evade …

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      Nucleic acids are utilized in many therapeutic modalities, including gene …

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      Nucleic acids are utilized in many therapeutic modalities, including gene …

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      Introduction. Species can be divided into altricial (helpless) and precocial (freely …

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  3. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185194

    A suppressive oligodeoxynucleotide expressing …

  4. Science | AAAS
    https://www.science.org/doi/10.1126/scitranslmed.abd3438

    Engineering adeno-associated viral vectors to evade …

    Tags:
    Viral Vectors
    Publish Year:2021
    Adenovirus Vector Production Titer
  5. Studies of ttaggg sequence and inflammation
    PubMed
    A suppressive oligodeoxynucleotide expressing TTAGGG motifs modulates cellular energetics through the mTOR signaling pathway
    Immune-mediated inflammation must be down-regulated to facilitate tissue remodeling during homeostatic restoration of an inflammatory response. Uncontrolled or over-exuberant immune activation can cause autoimmune diseases, as well as tissue destruction.
    Author: Volkan Yazar
    Published: 2020/01/09
    Keywords: A151 ODN…
    National Center for Biotechnology Information
    A suppressive oligodeoxynucleotide expressing TTAGGG motifs modulates cellular energetics through the mTOR signaling pathway
    The immunosuppressive ODN A151 profoundly affects mTOR signaling Keywords: A151 ODN, immunometabolism, immunosuppression, microarray
    Author: Volkan Yazar, …
    Published: 2020/01
    Publication: Int Immun…
    National Center for Biotechnology Information
    Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes
    The recognition of microbial DNA is a major mechanism by which the immune system detects pathogens. Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that activates innate immune responses through production of the second messenger cGAMP,
    Author: Folkert Steinh…
    Published: 2018/04
    DOI: 10.1002/eji.20174…
    ScienceDirect
    Invited review Structure, mechanism and therapeutic utility of immunosuppressive oligonucleotides
    Synthetic oligodeoxynucleotides that can down-regulate cellular elements of the immune system have been developed and are being widely studied in preclinical models. These agents vary in sequence, mechanism of action, and cellular target(s) but share
    Published: 2016/03/01
    Cited By: 26
    Page Count: 10
    PubMed
    Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes
    Type I interferon (IFN) is a critical mediator of autoimmune diseases such as systemic lupus erythematosus (SLE) and Aicardi-Goutières Syndrome (AGS). The recently discovered cyclic-GMP-AMP (cGAMP) synthase (cGAS) induces the production of type I IFN
    Author: Folkert Steinh…
    Published: 2018/4
    Keywords: Autoimmun…
    National Center for Biotechnology Information
    Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive TTAGGG Motifs Inhibit AIM2 Inflammasome Activation
    Synthetic oligodeoxynucleotides comprised of the immunosuppressive motif TTAGGG block TLR9 signaling, prevent STAT1 and STAT4 phosphorylation and attenuate a variety of inflammatory responses in vivo. Here, we demonstrate that such suppressive oligodeoxynucleotides
    Author: John J. Kamin…
    Published: 2013/10/10
    DOI: 10.4049/jimmunol.…
    National Center for Biotechnology Information
    Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats
    The immune system plays a fundamental role in both the development and pathobiology of stroke. Inflammasomes are multiprotein complexes that have come to be recognized as critical players in the inflammation that ultimately contributes to stroke severity.
    Author: Jing Zhao, Yo…
    Published: 2015
    Publication: PLoS On…
    PubMed
    A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
    A highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library. Quantitative hybridization to chromosomes sorted by flow cytometry indicates that comparable amounts of this sequence are present
    Author: R K Moyzis
    Published: 1988/9
    Keywords: National In…
    National Center for Biotechnology Information
    Conservation of the human telomere sequence (TTAGGG)n among vertebrates.
    To determine the evolutionary origin of the human telomere sequence (TTAGGG)n, biotinylated oligodeoxynucleotides of this sequence were hybridized to metaphase spreads from 91 different species, including representative orders of bony fish, reptiles,
    Author: J Meyne, R L …
    Published: 1989/09
    Publication: Proc Natl …
  6. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386451

    Suppressive oligodeoxynucleotides containing TTAGGG …

    Tags:
    Odn A151
    Repetitive DNA
    Publish Year:2018
    Published:2018/04
  7. Science | AAAS
    https://www.science.org/doi/pdf/10.1126/scitranslmed.abd3438?download=true
    [PDF]

    GENE THERAPY Engineering adeno-associated …

  8. ScienceDirect
    https://www.sciencedirect.com/science/article/abs/pii/S1043661815301651

    Structure, mechanism and therapeutic utility of …

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    Defne Bayik, Ihsan Gursel, Dennis M. Klinman
    Publish Year:2016
  9. People also ask
    Do TTAGGG proteins bind to nontelomeric DNA sequences?However, very little is known on the binding of these proteins to nontelomeric DNA sequences. The TTAGGG DNA repeat proteins 1 and 2 (TRF1 and TRF2) bind to mammalian telomeres as part of the shelterin complex and are essential for maintaining chromosome end stability.

    The human TTAGGG repeat factors 1 and 2 bind to a subset of ... - Natu…

    nature.com
    What causes elevated TTG?
    primaryExpertImage

    Dr. Howard E. LeWine

    M.D. Chief Medical Editor, Harvard Health Publishing · 40 years of exp

    An elevated blood level of TTG (tissue transglutaminase) supports a diagnosis of celiac disease. Celiac disease (also called gluten-sensitive enteropathy) is an intestinal disorder in which the body cannot tolerate gluten. Gluten is a natural protein in many grains, including wheat, barley, rye and oats. People with celiac disease have an immune reaction that is triggered by gluten. The immune reaction causes inflammation at the surface of the small intestine where it damages the surface of the intestine. When they are damaged, the intestine cannot absorb nutrients properly.
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    Does TTAGGG suppress CpG-induced TLR9 phosphorylation?Data are presented as mean ± SD from three biological replicates representative of three experiments. Previous studies have shown that the deoxyguanosine residues found within A151’s TTAGGG motif play a role in suppression of CpG-induced TLR9 signaling as well as STAT1 and STAT4 phosphorylation.

    Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive TTAGGG

    ncbi.nlm.nih.gov
    What does TTAGGG stand for?A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. A highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library.

    A highly conserved repetitive DNA sequence, (TTAGGG)n, present at th…

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  10. Nature
    https://www.nature.com/articles/s41419-023-06140-0

    Inhibition of cGAS–STING pathway alleviates ... - Nature

  11. PNAS
    https://www.pnas.org/doi/10.1073/pnas.85.18.6622

    A highly conserved repetitive DNA sequence, …

    Tags:
    Repetitive DNA
    Conserved Dna Sequence
    Highly Repetitive Sequence
  12. American Association of Immunologists
    https://journals.aai.org/jimmunol/article/191/7/...

    Synthetic Oligodeoxynucleotides Containing Suppressive …

    Tags:
    TLR9
    TTAGGG
  13. PubMed
    https://pubmed.ncbi.nlm.nih.gov/29215161

    Suppressive oligodeoxynucleotides containing TTAGGG motifs …

    Tags:
    Odn A151
    Repetitive DNA
    Publish Year:2018
  14. Nature
    https://www.nature.com/articles/cr201140

    The human TTAGGG repeat factors 1 and 2 bind to a subset of

    Tags:
    TTAGGG Repeat Factors
    Publish Year:2011
    Ttaggg Repeats in What Cell
  15. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878640

    Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive …

    Tags:
    Publish Year:2013
    10.4049/jimmunol.1300530
    Published:2013/10/10
  16. UCL Discovery
    https://discovery.ucl.ac.uk/id/eprint/10121916/31/Dick_Main Text Final.pdf
    [PDF]

    Engineering adeno-associated viral vectors to evade innate …

    Tags:
    Viral Vectors
    TLR9
  17. Oxford Academic
    https://academic.oup.com/intimm/article/32/1/39/5601533

    suppressive oligodeoxynucleotide expressing TTAGGG motifs …

    Tags:
    Odn A151
    Publish Year:2020
  18. PNAS
    https://www.pnas.org/doi/10.1073/pnas.86.18.7049

    Conservation of the human telomere sequence (TTAGGG)n …

  19. MDPI
    https://www.mdpi.com/1422-0067/22/2/590

    IJMS | Free Full-Text | Molecular Aspects of Senescence and

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    Publish Year:2021
    Natalia Sławińska, Renata Krupa
  20. Nature
    https://www.nature.com/articles/cr201140.pdf
    [PDF]

    The human TTAGGG repeat factors 1 and 2 bind to a subset …

    Tags:
    Publish Year:2011
    TTAGGG Repeat Factors
  21. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608557

    Synthetic Oligodeoxynucleotides Containing Multiple Telemeric …

    Tags:
    Publish Year:2015
    10.1371/journal.pone.0140772
    Published:2015
  22. Oxford Academic
    https://academic.oup.com/jhered/article/93/4/282/2187315

    Conservation of (TTAGG)n Telomeric Sequences Among Ants …

    Tags:
    P. Lorite, J. A. Carrillo, T. Palomeque
    Publish Year:2002
  23. PubMed
    https://pubmed.ncbi.nlm.nih.gov/3413114

    A highly conserved repetitive DNA sequence, (TTAGGG)n, …

    Tags:
    Repetitive DNA
    Human Telomere Ttaggg
    Conserved Dna Sequence
  24. Nature
    https://www.nature.com/articles/6887090

    Physical mapping of rDNA genes, ( TTAGGG )n telomeric …

    Tags:
    Roberto Vitturi, Maria Stella Colomba, Anna Pirrone, Angelo Libertini
    Publish Year:2000
  25. harvard.edu
    https://news.harvard.edu/gazette/story/2024/06/...

    Women who follow Mediterranean diet live longer — Harvard …

  26. Nature
    https://www.nature.com/articles/s41586-024-07501-1

    A disease-associated gene desert directs macrophage …

  27. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC297991

    Conservation of the human telomere sequence (TTAGGG)n …

    Tags:
    Human Telomere Ttaggg
    Publish Year:1989
    10.1073/pnas.86.18.7049
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