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Review article The emerging roles of lysine-specific demethylase …
WEBMar 1, 2024 · Lysine-specific demethylase 4 A (KDM4A, also named JMJD2A, KIA0677, or JHDM3A) is a demethylase that can remove methyl groups from histones H3K9me2/3, …
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Essential role of the histone lysine demethylase KDM4A in the
WEBJun 4, 2021 · The results establish a novel and essential role for KDM4A in growth in preclinical models of MPM and identify potential therapeutic approaches to target …
- Author: Moshe Lapidot, Abigail E Case, Ellen L Weisberg, Chengcheng Meng, Sarah R Walker, Swati Garg, Wei Ni...
- Publish Year: 2021
- Studies of kdm4a redox
Mechanistic insights into KDM4A driven genomic instability
WEBFeb 2, 2021 · KDM4A modulates re-replication of distinct genomic loci, activates cell cycle inducers, and represses proteins involved in checkpoint control giving rise to proliferative …
- Author: Nicolas L Young, Ruhee Dere
- DOI: 10.1042/BST20191219
- Publish Year: 2021
- Published: 2021/02/02
KDM4 orchestrates epigenomic remodeling of …
WEBPublished: 13 May 2021. KDM4 orchestrates epigenomic remodeling of senescent cells and potentiates the senescence-associated secretory …
- Author: Boyi Zhang, Qilai Long, Shanshan Wu, Qixia Xu, Shuling Song, Liu Han, Min Qian, Xiaohui Ren, Hanxin ...
- Publish Year: 2021
Histone demethylases in the regulation of immunity and …
WEBJun 23, 2023 · Facts. Abnormal expression of KDMs play a crucial role in the pathogenesis of inflammatory diseases. KDMs regulate the development and function of immune cells …
The lysine demethylase KDM4A controls the cell-cycle …
WEBThe histone lysine tri-demethylase KDM4A is regulated over cell cycle and plays a direct role in DNA replication timing, site-specific rereplication, and DNA amplifications during …
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WEBKDM4A controls invasive growth and immune evasion during SCC development. KDM4A loss induces liquid-like HP1g puncta and DNA replication stress in SCC. KDM4A loss …
KDM4A regulates myogenesis by demethylating H3K9me3 of …
WEBMay 19, 2021 · Histone lysine demethylase 4A (KDM4A) plays a crucial role in regulating cell proliferation, cell differentiation, development and tumorigenesis. However, little is …
KDM4A, involved in the inflammatory and oxidative stress caused …
WEBMar 3, 2023 · KDM4A, involved in the inflammatory and oxidative stress caused by traumatic brain injury-hemorrhagic shock, partly through the regulation of the microglia …
In-silico guided chemical exploration of KDM4A fragments hits
WEBDec 21, 2023 · KDM4A isoform plays an important role in the epigenetic dysregulation in various cancers and is linked to aggressive disease and poor clinical outcomes. Despite …
KDM4A regulates myogenesis by demethylating H3K9me3 of
WEBMay 19, 2021 · 15 Citations. 2 Altmetric. Metrics. Abstract. Histone lysine demethylase 4A (KDM4A) plays a crucial role in regulating cell proliferation, cell differentiation, …
KDM4 Demethylases: Structure, Function, and Inhibitors
WEBSep 27, 2023 · The KDM4 proteins mainly catalyze demethylation on tri- and di-methylated histone H3 lysine 9 (H3K9me3/me2), histone marks associated with gene repression and found in the heterochromatin. In addition, KDM4A-C catalyzes the demethylation of H3K36me3/me2, H3K27me3/me2, and possibly non-histone proteins, albeit at a lower rate.
WEBWe describe the use of combined molecular dynamics (MD) and Quantum Mechanical/Molecular Mechanical (QM/MM) methods to study the mechanism of …
KDM4 Involvement in Breast Cancer and Possible Therapeutic
WEBOct 28, 2021 · Specifically, the KDM4 gene family comprises six members, KDM4A-F, which are associated with oncogene activation, tumor suppressor silencing, alteration of …
Histone demethylase KDM4A plays an oncogenic role in ... - Nature
WEBAug 12, 2021 · 10 Citations. 1 Altmetric. Metrics. Abstract. Compelling evidence has indicated the vital role of lysine-specific demethylase 4 A (KDM4A), hypoxia-inducible …
The Activity of JmjC Histone Lysine Demethylase KDM4A is …
WEBAt 1% O2, KDM4A was 40% less effective as a histone demethylase than at 21%, and had virtually no activity at 0.1% [68]. KDM4 enzymes are less sensitive to O2 changes …
Targeting KDM4A Epigenetically Activates Tumor Cell-intrinsic …
WEBMay 5, 2021 · PMCID: PMC8141018. NIHMSID: NIHMS1685125. PMID: 33743195. Targeting KDM4A Epigenetically Activates Tumor Cell-intrinsic Immunity by Inducing …
The Histone Demethylase KDM4A Is Required to Sustain …
WEBNov 29, 2018 · The KDM4A-21 score can be calculated for each patient as the weighted sum of expressions of the 21 genes. The score high patients in a number of large de …
KDM4 Involvement in Breast Cancer and Possible Therapeutic …
WEBKDM4A in BC. KDM4A mainly demethylates H3K9me2/me3 and, at a lower rate, H3K36me2/me3 in vivo and H1.4K26me3 in vitro ( 17 ), promoting chromatin …
Targeting KDM4A epigenetically activates tumor-cell-intrinsic …
WEBSummary. Developing strategies to activate tumor-cell-intrinsic immune response is critical for improving tumor immunotherapy by exploiting tumor vulnerability. KDM4A, as a …
Frontiers | A KDM4-DBC1-SIRT1 Axis Contributes to TGF-b …
WEBSep 22, 2021 · KDM4A depletion or inhibition abrogated DBC1 induction by TGF-β and normalized SIRT1 activity. In addition, KDM4A deficiency attenuated TGF-β induced …
Iron metabolism: backfire of cancer cell stemness and therapeutic ...
WEB4 days ago · Iron exists in two redox states, namely, oxidized ferric iron (Fe 3+) and reduced ferrous iron (Fe 2+). In a standard diet, plant-derived inorganic iron (Fe 3+) …
WEBHistone lysine demethylase 4A (KDM4A) plays a crucial role in regulating cell proliferation, cell differentiation, development and tumorigenesis. However, little is known about the...
The histone demethylase JMJD2A/KDM4A links ribosomal RNA …
WEBOpen access. Published: 05 January 2016. The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability. Kader Salifou, …
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