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- Some of the latest news on mantle cell lymphoma, a form of blood cancer, are the FDA approval of a new type of BTK inhibitor, pirtobrutinib, for patients with relapsed or refractory disease1, the discovery of a gene expression regulator, BRD4, that is essential for the growth of this lymphoma and can be targeted by an experimental drug2, and the identification of small molecule inhibitors of the SOX11 oncogene, which is expressed in most mantle cell lymphoma patients and promotes tumor development3.
Learn more:✕This summary was generated using AI based on multiple online sources. To view the original source information, use the "Learn more" links.FDA Approves New Type of BTK Inhibitor to Treat Mantle Cell Lymphoma Rye Brook, N.Y., January 27, 2023 – The U.S. Food and Drug Administration today approved pirtobrutinib (Jaypirca™), the first non-covalent, reversable BTK inhibitor for the treatment of adults with mantle cell lymphoma that has worsened or returned despite earlier treatment.www.lls.org/news/fda-approves-new-type-btk-inhibi…A form of blood cancer known as mantle cell lymphoma is critically dependent on a protein that coordinates gene expression, such that blocking its activity with an experimental drug dramatically slows the growth of this lymphoma in preclinical tests, according to a study from Weill Cornell Medicine researchers.news.cornell.edu/stories/2022/11/discovery-sugges…One recent study published in Clinical Cancer Research revealed that small molecule inhibitors of the SOX11 oncogene are toxic to MCL tumor development in human cells studied outside the body.“The SOX11 protein, which is expressed in up to 90% of mantle cell lymphoma patients, is an attractive target for therapy,” study author Samir Parekh, MD, professor of medicine, Icahn School of Medicine at Mount Sinai, said in a press...
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WEBMay 15, 2024 · As reported in The Lancet by Martin Dreyling, MD, PhD, and colleagues, results in the European Mantle Cell Lymphoma Network phase III TRIANGLE trial …
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Frontline Treatment of Mantle Cell Lymphoma
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FDA Approves Breyanzi for Mantle Cell Lymphoma
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WEBJun 29, 2022 · Accounting for 5 to 7% of all lymphomas, mantle-cell lymphoma has historically been associated with a poor outcome, but survival is improving. The …
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WEBMay 30, 2024 · Mantle cell lymphoma (MCL) is an aggressive, rare form of non-Hodgkin lymphoma (NHL), representing roughly 3% of all NHL cases. MCL originates from cells …
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WEBDec 11, 2023 · The phase 2 trial PrE0405 met its primary endpoint, achieving a complete response (CR) rate of 85% in 33 patients over the age of 60 with mantle cell lymphoma …
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WEBJun 29, 2022 · There is considerable variation in the management of mantle cell lymphoma across different clinical settings, and some strategies do not always conform …
Long-Term Survival of Patients with Mantle Cell Lymphoma after …
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WEBThis page features news articles, interviews in written and video format, and podcasts that focus on unmet needs, therapeutic advances, and ongoing research in mantle cell …
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WEBFeb 27, 2024 · Mantle cell lymphoma is a rare and aggressive form of cancer affecting the lymphatic system. Learn more about its symptoms, treatment, and outlook.
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