odn ttaggg a151 - Search

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Studies of odn ttaggg a151
National Center for Biotechnology Information
Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive TTAGGG Motifs Inhibit AIM2 Inflammasome Activation
Synthetic oligodeoxynucleotides comprised of the immunosuppressive motif TTAGGG block TLR9 signaling, prevent STAT1 and STAT4 phosphorylation and attenuate a variety of inflammatory responses in vivo. Here, we demonstrate that such suppressive oligodeoxynucleotides
Author: John J. Kamin…
Published: 2013/10/10
DOI: 10.4049/jimmunol.…
PubMed
A suppressive oligodeoxynucleotide expressing TTAGGG motifs modulates cellular energetics through the mTOR signaling pathway
Immune-mediated inflammation must be down-regulated to facilitate tissue remodeling during homeostatic restoration of an inflammatory response. Uncontrolled or over-exuberant immune activation can cause autoimmune diseases, as well as tissue destruction.
Author: Volkan Yazar
Published: 2020/01/09
Keywords: A151 ODN…
National Center for Biotechnology Information
Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes
The recognition of microbial DNA is a major mechanism by which the immune system detects pathogens. Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that activates innate immune responses through production of the second messenger cGAMP,
Author: Folkert Steinh…
Published: 2018/04
DOI: 10.1002/eji.20174…
National Center for Biotechnology Information
Advances in the mechanisms and applications of inhibitory oligodeoxynucleotides against immune-mediated inflammatory diseases
Inhibitory oligodeoxynucleotides (ODNs) are short single-stranded DNA, which capable of folding into complex structures, enabling them to bind to a large variety of targets. With appropriate modifications, the inhibitory oligodeoxynucleotides exhibited
Author: Hongrui Wang…
Published: 2023
Publication: Front Pha…
PubMed
Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes
Type I interferon (IFN) is a critical mediator of autoimmune diseases such as systemic lupus erythematosus (SLE) and Aicardi-Goutières Syndrome (AGS). The recently discovered cyclic-GMP-AMP (cGAMP) synthase (cGAS) induces the production of type I IFN
Author: Folkert Steinh…
Published: 2018/4
Keywords: Autoimmun…
PubMed
Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation
Synthetic oligodeoxynucleotides (ODNs) comprised of the immunosuppressive motif TTAGGG block TLR9 signaling, prevent STAT1 and STAT4 phosphorylation and attenuate a variety of inflammatory responses in vivo. In this study, we demonstrate that such suppressive
Author: John J Kaminski
Published: 2013/10/01
Keywords: National In…
National Center for Biotechnology Information
Structure, mechanism and therapeutic utility of immunosuppressive oligonucleotides
Nucleic acids are the “blueprint of life” and thus essential components of all living organisms. DNA and RNA also have multiple and complex effects on the immune system [1–3]. The nucleic acids present in pathogenic microorganisms can trigger toll-like
Author: Defne Bayik, I…
Published: 2016/03
DOI: 10.1016/j.phrs.201…
PubMed
Gene network landscape of mouse splenocytes reveals integrin complex as the A151 ODN-responsive hub molecule in the immune transcriptome
Homeostatic restoration of an inflammatory response requires quenching of the immune system after pathogen threats vanish. A continued assault orchestrated by host defense results in tissue destruction or autoimmunity. A151 is the epitome of synthetic
Author: Volkan Yazar
Published: 2023/02/04
Keywords: A151 oligod…
PubMed
A suppressive oligodeoxynucleotide inhibits ocular inflammation
Synthetic oligodeoxynucleotides (ODN) expressing 'suppressive' TTAGGG motifs down-regulate a variety of proinflammatory and T helper type 1 (Th1)-mediated pathological immune responses. The ability of the archetypal suppressive ODN A151 to inhibit
Author: C Fujimoto
Published: 2009/6
Keywords: National In…
PubMed
AIM2 inflammasome activation benefits the therapeutic effect of BCG in bladder carcinoma
A large proportion of bladder cancer (BLCA) patients suffer from malignant progression to life-threatening muscle-invasive bladder cancer (MIBC). Inflammation is a critical event in cancer development, but little is known about the role of inflammation
Author: Houhong Zhou
Published: 2022/10/31
Keywords: AIM2; BC…
InvivoGen
https://www.invivogen.com/odnttaggg
ODN TTAGGG A151 | TLR9, AIM2, IFI16 & cGAS antagonist
WEBODN TTAGGG (A151) is a synthetic oligonucleotide containing the immunosuppressive motif TTAGGG. This ODN is a multiple pattern recognition receptors suppressor that can …
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- ODN TTAGGG (A151) - In…
  ODN TTAGGG (A151), also known simply as A151, is a synthetic oligonucleotide …
- ODN TTAGGG (A151) Co…
  ODN TTAGGG (A151), also known as A151, is a synthetic oligonucleotide (ODN) …
- Validation data for ODN TT…
  ODN TTAGGG (A151) is a synthetic oligonucleotide (ODN) containing 4 …
- TLR9 Antagonists: ligands t…
  ODN 2088; ODN 2088 control; ODN 4084-F; ODN INH-18; ODN TTAGGG (A151) …
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Nature
https://www.nature.com/articles/s41419-023-06140-0
Inhibition of cGAS–STING pathway alleviates ... - Nature
WEBSep 19, 2023 · ODN TTAGGG, also known as A151, is a synthetic oligonucleotide comprising the immunosuppressive TTAGGG motif, and it is a novel inhibitor of cGAS …
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The cGAS–STING pathway as a therapeutic target in ... - …
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The role of STING signaling in central nervous system …
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National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878640
Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive …
WEBOct 1, 2013 · Here, we demonstrate that such suppressive oligodeoxynucleotides (sup ODN) abrogate activation of cytosolic nucleic acid sensing pathways. Pretreatment of …
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ODN TTAGGG
Publish Year:2013
10.4049/jimmunol.1300530
PubMed
https://pubmed.ncbi.nlm.nih.gov/31633763
A suppressive oligodeoxynucleotide expressing TTAGGG motifs …
WEBJan 9, 2020 · A151, the archetypal example of a chemically synthesized suppressive oligodeoxynucleotide (ODN) based on repetitive telomere-derived TTAGGG …
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Odn A151
ODN TTAGGG
Autoimmune Conditions and Diseases
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386451
Suppressive oligodeoxynucleotides containing TTAGGG motifs …
WEBIn this study, we demonstrate that the suppressive ODN A151 effectively inhibits activation of cGAS in response to cytosolic DNA, thereby inhibiting type I IFN production by human …
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Odn A151
Publish Year:2018
Published:2018/04
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941346
Advances in the mechanisms and applications of inhibitory ...
WEBFeb 7, 2023 · As a typical inhibitory ODN with poly G, A151 with tandem repeat sequence “TTAGGG” derived from the telomeres of mammalian chromosomes was well …
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Odn A151
Front Pharmacol. 2023; 14: 1119431.
Published:2023
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What is ODN TTAGGG?ODN TTAGGG, also known as A151, is a synthetic oligonucleotide comprising the immunosuppressive TTAGGG motif, and it is a novel inhibitor of cGAS and AIM2 by competing with DNA [ 23, 24 ].
Inhibition of cGAS–STING pathway alleviates ... - Nature
nature.com
Does ODN TTAGGG (A151) inhibit CDs activity?Inhibition of CDS activity with ODN TTAGGG (A151) can be studied in a variety of cells, including THP1-DualTM cells which express multiple CDSs and an interferon regulatory factor (IRF)-inducible Lucia luciferase reporter gene.
ODN TTAGGG (A151) - InvivoGen
invivogen.com
How do you store ODN TTAGGG (A151)?ODN TTAGGG (A151) is shipped at room temperature. Upon receipt, store at -20 °C. Upon resuspension, store aliquots at -20 °C. Resuspended product is stable for 6 months at -20 °C when properly stored. Avoid repeated freeze-thaw cycles. Biological activity has been tested using HEK-BlueTM TLR9 cells.
ODN TTAGGG (A151) - InvivoGen
invivogen.com
Does a sup ODN A151 prevent activation of cytosolic DNA sensing pathways?This work is the first to identify a DNA species capable of preventing activation of cytosolic DNA sensing pathways. Moreover it establishes a novel mechanism through which the sup ODN A151 mediates suppression of innate immune responses via interaction with members of the IFI20X/IFI16 (PYHIN) family.
Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive TTAGGG
ncbi.nlm.nih.gov
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PubMed
https://pubmed.ncbi.nlm.nih.gov/29215161
Suppressive oligodeoxynucleotides containing TTAGGG motifs …
WEBIn this study, we demonstrate that the suppressive ODN A151 effectively inhibits activation of cGAS in response to cytosolic DNA, thereby inhibiting type I IFN production by human …
Tags:
Odn A151
Publish Year:2018
American Association of Immunologists
https://journals.aai.org/jimmunol/article/…
Synthetic Oligodeoxynucleotides Containing …
WEBOct 1, 2013 · Pretreatment of dendritic cells and macrophages with the suppressive ODN-A151 abrogated type I IFN, TNF-α, and ISG induction in response to cytosolic dsDNA. In addition, A151 abrogated caspase …
PubMed
https://pubmed.ncbi.nlm.nih.gov/23986531
Synthetic oligodeoxynucleotides containing suppressive …
WEBOct 1, 2013 · In this study, we demonstrate that such suppressive ODN abrogate activation of cytosolic nucleic acid-sensing pathways. Pretreatment of dendritic cells and …
Tags:
TTAGGG
Publish Year:2013
fishersci.com
https://www.fishersci.com/shop/products/odn-ttaggg...
Invivogen ODN TTAGGG (A151), 1 mg - Fisher Scientific
WEBODN TTAGGG (A151), also known simply as A151, is a synthetic oligonucleotide (ODN) containing 4 repeats of the immunosuppressive TTAGGG motif commonly found in …
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Odn A151
ODN TTAGGG
Wiley Online Library
https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.201747338
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Suppressive oligodeoxynucleotides containing TTAGGG …
WEBJul 12, 2017 · Synthetic oligonucleotides (ODN) containing repetitive TTAGGG motifs (ODN A151) mimic the abil-ity of telomeric DNA and inhibit the development of …
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Odn A151
ODN TTAGGG
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417099
Structure, mechanism and therapeutic utility of …
WEBThis work reviews the types of immunosuppressive oligodeoxynucleotide (Sup ODN) and compares their therapeutic activity against diseases characterized by pathologic levels …
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Publish Year:2016
10.1016/j.phrs.2015.11.010
Published:2016/03
Springer
https://link.springer.com/article/10.1007/s11095-018-2344-2
Targeting Suppressive Oligonucleotide to Lymph Nodes
WEBFeb 8, 2018 · 15 Citations. 4 Altmetric. Explore all metrics. Abstract. Purpose. This paper aims to investigate the immunoinhibitory properties of a lymph nodes-targeting …
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Publish Year:2018
Chunsong Yu, Myunggi An, Evan Jones, Haipeng Liu
Frontiers
https://www.frontiersin.org/journals/pharmacology/...
Frontiers | AIM2 inflammasome activation benefits the therapeutic ...
WEBOct 30, 2022 · In addition, oligodeoxynucleotide (ODN) TTAGGG (A151), an AIM2 inflammasome inhibitor, could abolish the elevation of AIM2-induced cleavage of …
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Odn A151
ODN TTAGGG
Wiley Online Library
https://onlinelibrary.wiley.com/doi/10.1002/eji.201747338
Suppressive oligodeoxynucleotides containing TTAGGG motifs …
WEBDec 7, 2017 · Synthetic oligonucleotides (ODN) containing repetitive TTAGGG motifs (ODN A151) mimic the ability of telomeric DNA and inhibit the development of …
Tags:
Odn A151
ODN TTAGGG
Publish Year:2018
PubMed
https://pubmed.ncbi.nlm.nih.gov/36895952
Gene network landscape of mouse splenocytes reveals integrin …
WEBFeb 4, 2023 · A151 is the epitome of synthetic oligodeoxynucleotides (ODNs) that curb the immune response by a subset of white corpuscles through repetitive telomere-derived …
MedChemExpress
https://www.medchemexpress.com/odn-ttaggg.html
ODN TTAGGG (ODN A151) | TLR Antagonist | MedChemExpress
WEBODN TTAGGG (A151), inhibitory oligonucleotide (ODN), is a TLR9, AIM2 and cGAS antagonist. ODN TTAGGG is immunosuppressive and inhibits AIM2 inflammasome …
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Odn A151
ODN TTAGGG
Aim2 Antagonist
PubMed
https://pubmed.ncbi.nlm.nih.gov/19438607
A suppressive oligodeoxynucleotide inhibits ocular inflammation
WEBPMCID: PMC2691983. DOI: 10.1111/j.1365-2249.2009.03918.x. Abstract. Synthetic oligodeoxynucleotides (ODN) expressing 'suppressive' TTAGGG motifs down-regulate a …
PubMed
https://pubmed.ncbi.nlm.nih.gov/36386141
AIM2 inflammasome activation benefits the therapeutic effect
WEBOct 31, 2022 · In addition, oligodeoxynucleotide (ODN) TTAGGG (A151), an AIM2 inflammasome inhibitor, could abolish the elevation of AIM2-induced cleavage of …
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