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  2. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409505

    Engineering adeno-associated viral vectors to evade innate …

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    Current issues in adeno-associated viral vector production
    nature.com
    Engineering adeno-associated virus vectors for gene therapy
    nature.com
    Anti-AAV Antibodies in AAV Gene Therapy: Current …
    pubmed.ncbi.nlm.nih.gov
    Synthetically Engineered Adeno-Associated Virus for …
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    Modifying immune responses to adeno-associated virus …
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  3. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185194

    A suppressive oligodeoxynucleotide expressing TTAGGG motifs …

  4. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878640

    Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive …

  5. Studies of site:ncbi.nlm.nih.gov ttaggg sequence and inflammation
    National Center for Biotechnology Information
    A suppressive oligodeoxynucleotide expressing TTAGGG motifs modulates cellular energetics through the mTOR signaling pathway
    The immunosuppressive ODN A151 profoundly affects mTOR signaling Keywords: A151 ODN, immunometabolism, immunosuppression, microarray
    Author: Volkan Yazar, …
    Published: 2020/01
    Publication: Int Immun…
    National Center for Biotechnology Information
    Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive TTAGGG Motifs Inhibit AIM2 Inflammasome Activation
    Synthetic oligodeoxynucleotides comprised of the immunosuppressive motif TTAGGG block TLR9 signaling, prevent STAT1 and STAT4 phosphorylation and attenuate a variety of inflammatory responses in vivo. Here, we demonstrate that such suppressive oligodeoxynucleotides
    Author: John J. Kamin…
    Published: 2013/10/10
    DOI: 10.4049/jimmunol.…
    PubMed
    A suppressive oligodeoxynucleotide expressing TTAGGG motifs modulates cellular energetics through the mTOR signaling pathway
    Immune-mediated inflammation must be down-regulated to facilitate tissue remodeling during homeostatic restoration of an inflammatory response. Uncontrolled or over-exuberant immune activation can cause autoimmune diseases, as well as tissue destruction.
    Author: Volkan Yazar
    Published: 2020/01/09
    Keywords: A151 ODN…
    PubMed
    Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes
    Type I interferon (IFN) is a critical mediator of autoimmune diseases such as systemic lupus erythematosus (SLE) and Aicardi-Goutières Syndrome (AGS). The recently discovered cyclic-GMP-AMP (cGAMP) synthase (cGAS) induces the production of type I IFN
    Author: Folkert Steinh…
    Published: 2018/4
    Keywords: Autoimmun…
    PubMed
    Therapeutic applications and mechanisms underlying the activity of immunosuppressive oligonucleotides
    Synthetic oligodeoxynucleotides (ODN) capable of "neutralizing" or "inhibiting" immune responses have been described. This review will focus on the properties of phosphorothioate ODN that mimic the immunosuppressive activity of the repetitive TTAGGG
    Author: Dennis M Klin…
    Published: 2009/9
    Keywords: National In…
    National Center for Biotechnology Information
    Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes
    The recognition of microbial DNA is a major mechanism by which the immune system detects pathogens. Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that activates innate immune responses through production of the second messenger cGAMP,
    Author: Folkert Steinh…
    Published: 2018/04
    DOI: 10.1002/eji.20174…
    National Center for Biotechnology Information
    Structure, mechanism and therapeutic utility of immunosuppressive oligonucleotides
    Nucleic acids are the “blueprint of life” and thus essential components of all living organisms. DNA and RNA also have multiple and complex effects on the immune system [1–3]. The nucleic acids present in pathogenic microorganisms can trigger toll-like
    Author: Defne Bayik, I…
    Published: 2016/03
    DOI: 10.1016/j.phrs.201…
    PubMed
    Telomere shortening during aging: Attenuation by antioxidants and anti-inflammatory agents
    Telomeres are a repeated sequence -of bases found at the ends of chromosomes. In humans, this sequence is TTAGGG, which is repeated over 2000 times. Telomeres protect the ends chromosomes from fusion with nearby chromosomes, and allow effective replication
    Author: Kedar N Prasad
    Published: 2017/6
    Keywords: Aging; Anti …
    National Center for Biotechnology Information
    Conservation of the human telomere sequence (TTAGGG)n among vertebrates.
    To determine the evolutionary origin of the human telomere sequence (TTAGGG)n, biotinylated oligodeoxynucleotides of this sequence were hybridized to metaphase spreads from 91 different species, including representative orders of bony fish, reptiles,
    Author: J Meyne, R L …
    Published: 1989/09
    Publication: Proc Natl …
    National Center for Biotechnology Information
    Advances in the mechanisms and applications of inhibitory oligodeoxynucleotides against immune-mediated inflammatory diseases
    Inhibitory oligodeoxynucleotides (ODNs) are short single-stranded DNA, which capable of folding into complex structures, enabling them to bind to a large variety of targets. With appropriate modifications, the inhibitory oligodeoxynucleotides exhibited
    Author: Hongrui Wang…
    Published: 2023
    Publication: Front Pha…
    National Center for Biotechnology Information
    Molecular Aspects of Senescence and Organismal Ageing—DNA Damage Response, Telomeres, Inflammation and Chromatin
    Cells can become senescent in response to stress. Senescence is a process characterised by a stable proliferative arrest. Sometimes it can be beneficial—for example, it can suppress tumour development or take part in tissue repair. On the other hand,
    Author: Natalia Sławiń…
    Published: 2021/01
    Publication: Int J Mol …
    PubMed
    A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
    A highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library. Quantitative hybridization to chromosomes sorted by flow cytometry indicates that comparable amounts of this sequence are present
    Author: R K Moyzis
    Published: 1988/9
    Keywords: National In…
    National Center for Biotechnology Information
    The Potential of Telomeric G-Quadruplexes Containing Modified Oligoguanosine Overhangs in Activation of Bacterial Phagocytosis and Leukotriene Synthesis in Human Neutrophils
    Human neutrophils are the first line of defense against bacterial and viral infections. They eliminate pathogens through phagocytosis, which activate the 5-lipoxygenase (5-LOX) pathway resulting in synthesis of leukotrienes. Using HPLC analysis, flow
    Author: Ekaterina A. G…
    Published: 2020/02
    Publication: Biomolec…
    National Center for Biotechnology Information
    Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9
    Our immune defense depends on two specialized armed forces. The innate force acts as an alarm mechanism that senses changes in the microenvironment through the recognition of common microbial patterns by Toll-like receptors (TLR) and NOD proteins. It
    Author: Petar S. Lenert
    Published: 2010
    Publication: Mediator…
    National Center for Biotechnology Information
    Synthetic oligonucleotides as modulators of inflammation
    Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs mimic the immunostimulatory activity of bacterial DNA. CpG ODN directly stimulate human B cells and plasmacytoid dendritic cells, promote the production of Th1 and proinflammatory
    Author: Dennis Klinma…
    Published: 2008/10
    Publication: J Leukoc …
    National Center for Biotechnology Information
    Role of AIM2 inflammasome in inflammatory diseases, cancer and infection
    The innate immune system is made up of a set of germ-line–encoded pattern recognition receptors (PRRs) which act as a shield against pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) [1]. The PRRs are classified
    Author: Bhesh Raj Sha…
    Published: 2019/11
    DOI: 10.1002/eji.20184…
    National Center for Biotechnology Information
    Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats
    The immune system plays a fundamental role in both the development and pathobiology of stroke. Inflammasomes are multiprotein complexes that have come to be recognized as critical players in the inflammation that ultimately contributes to stroke severity.
    Author: Jing Zhao, Yo…
    Published: 2015
    Publication: PLoS On…
    National Center for Biotechnology Information
    The Human Telomere Sequence, (TTAGGG)4, in the Absence and Presence of Cosolutes: A Spectroscopic Investigation
    Historically, biophysical studies of nucleic acids have been carried out under near ideal conditions, i.e., low buffer concentration (e.g., 10 mM phosphate), pH 7, low ionic strength (e.g., 100 mM) and, for optical studies, low concentrations of DNA (e.g.,
    Author: Vishal R. Shar…
    Published: 2014/01
    Publication: Molecules…
    National Center for Biotechnology Information
    Shelterin Complex at Telomeres: Implications in Ageing
    Different factors influence the development‎ and control of ageing. It is well known that progressive telomere shorting is one of the molecular mechanisms underlying ageing. The shelterin complex consists of six telomere-specific proteins which are
    Author: Seyed Mostaf…
    Published: 2020
    Publication: Clin Inter…
    National Center for Biotechnology Information
    Sequence-Specific Recognition and Cleavage of Telomeric Repeat (TTAGG)n by Endonuclease of Non-Long Terminal Repeat Retrotransposon TRAS1
    The telomere of the silkworm Bombyx mori consists of (TTAGG/CCTAA)n repeats and harbors a large number of telomeric repeat-specific non-long terminal repeat retrotransposons, such as TRAS1 and SART1. To understand how these retrotransposons recognize
    Author: Tomohiro Anz…
    Published: 2001/01
    Publication: Mol Cell B…
    National Center for Biotechnology Information
    Human Telomerase and Its Regulation
    The telomere is a special functional complex at the end of linear eukaryotic chromosomes, consisting of tandem repeat DNA sequences and associated proteins. It is essential for maintaining the integrity and stability of linear eukaryotic genomes. Telomere
    Author: Yu-Sheng Con…
    Published: 2002/09
    Publication: Microbiol …
    National Center for Biotechnology Information
    The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats
    The study of the proteins that bind to telomeric DNA in mammals has provided a deep understanding of the mechanisms involved in chromosome-end protection. However, very little is known on the binding of these proteins to nontelomeric DNA sequences. The
    Author: Thomas Simo…
    Published: 2011/07
    Publication: Cell Res. …
  6. PubMed
    https://pubmed.ncbi.nlm.nih.gov/31633763

    A suppressive oligodeoxynucleotide expressing TTAGGG motifs …

    Tags:
    Odn A151
    Publish Year:2020
    Immune System
  7. PubMed
    https://pubmed.ncbi.nlm.nih.gov/29215161

    Suppressive oligodeoxynucleotides containing TTAGGG motifs …

    Tags:
    Repetitive DNA
    Odn A151
    Publish Year:2018
  8. PubMed
    https://pubmed.ncbi.nlm.nih.gov/19796080

    Therapeutic applications and mechanisms underlying the activity …

    Tags:
    Immune System
    TTAGGG
  9. People also ask
    How many times a chromosome is TTAGGG repeated?In humans, this sequence is TTAGGG, which is repeated over 2000 times. Telomeres protect the ends chromosomes from fusion with nearby chromosomes, and allow effective replication of DNA. Each time a cell divides, 25-200 base pairs are lost from the terminal sequence of chromosomes.

    Telomere shortening during aging: Attenuation by antioxidants and anti

    pubmed.ncbi.nlm.nih.gov
    What does TTAGG stand for?Sequence-Specific Recognition and Cleavage of Telomeric Repeat (TTAGG)nby Endonuclease of Non-Long Terminal Repeat Retrotransposon TRAS1 Tomohiro Anzai, Hidekazu Takahashi, and Haruhiko Fujiwara*

    Sequence-Specific Recognition and Cleavage of Telomeric

    ncbi.nlm.nih.gov
    What is the 5′ end of (TTAGG)n(G-strand)?The 5′ end of (TTAGG)n(G-strand) or (CCTAA)n(C-strand) was radiolabeled and annealed with the nonlabeled complementary oligonucleotide of the same length. In all experiments, only one strand of the double-stranded substrate was end labeled.

    Sequence-Specific Recognition and Cleavage of Telomeric

    ncbi.nlm.nih.gov
    Does A151 prevent CGAS activation in Trex1-deficient monocytes?In addition, A151 abrogated cGAS activation in response to endogenous accumulation of DNA using TREX1-deficient monocytes. We demonstrate that A151 prevents cGAS activation in a manner that is competitive with DNA. This suppressive activity of A151 was dependent on both telomeric sequence and phosphorothioate backbone.

    Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit c…

    pubmed.ncbi.nlm.nih.gov
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  10. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386451

    Suppressive oligodeoxynucleotides containing TTAGGG motifs …

    Tags:
    Repetitive DNA
    Odn A151
    Publish Year:2018
    Published:2018/04
  11. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417099

    Structure, mechanism and therapeutic utility of …

    Tags:
    Publish Year:2016
    10.1016/j.phrs.2015.11.010
    Published:2016/03
  12. PubMed
    https://pubmed.ncbi.nlm.nih.gov/28431907

    Telomere shortening during aging: Attenuation by antioxidants

    Tags:
    Publish Year:2017
    Chromosomes
  13. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC297991

    Conservation of the human telomere sequence (TTAGGG)n …

    Tags:
    Human Telomere Ttaggg
    Publish Year:1989
    10.1073/pnas.86.18.7049
  14. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941346

    Advances in the mechanisms and applications of inhibitory ...

    Tags:
    Repetitive DNA
    Front Pharmacol. 2023; 14: 1119431.
    Published:2023
  15. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827783

    Molecular Aspects of Senescence and Organismal Ageing—DNA …

    Tags:
    Repetitive DNA
    Publish Year:2021
    DNA Damage Response
  16. PubMed
    https://pubmed.ncbi.nlm.nih.gov/3413114

    A highly conserved repetitive DNA sequence, (TTAGGG)n, …

    Tags:
    Repetitive DNA
    Human Telomere Ttaggg
    Conserved Dna Sequence
  17. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072695

    The Potential of Telomeric G-Quadruplexes Containing Modified ...

    Tags:
    Publish Year:2020
    The Potential of Telomeric
    Biomolecules. 2020 Feb; 10(2): 249.
  18. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873634

    Classification, Mechanisms of Action, and Therapeutic …

    Tags:
    Petar S. Lenert
    Publish Year:2010
    Mediators Inflamm. 2010; 2010: 986596.
  19. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538593

    Synthetic oligonucleotides as modulators of inflammation - PMC

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    Dennis Klinman, Hidekazu Shirota, Debra Tross, Takashi Sato, Sven Klaschik
  20. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015662

    Role of AIM2 inflammasome in inflammatory diseases, cancer …

    Tags:
    Publish Year:2019
    Published:2019/11
  21. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608557

    Synthetic Oligodeoxynucleotides Containing Multiple Telemeric …

    Tags:
    Publish Year:2015
    10.1371/journal.pone.0140772
    Published:2015
  22. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271192

    The Human Telomere Sequence, (TTAGGG)4, in the Absence …

    Tags:
    Human Telomere Ttaggg
    Vishal R Sharma, Richard D Sheardy
  23. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276337

    Shelterin Complex at Telomeres: Implications in Ageing - PMC

    Tags:
    Repetitive DNA
    Publish Year:2020
    Shelterin Complex
  24. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC88784

    Sequence-Specific Recognition and Cleavage of Telomeric …

    Tags:
    Publish Year:2001
    Published:2001/01
  25. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC120798

    Human Telomerase and Its Regulation - PMC - National Center …

    Tags:
    Components of Telomerase
    Human Telomerase
    Direction of Telomerase
  26. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193489

    The human TTAGGG repeat factors 1 and 2 bind to a subset of ...

    Tags:
    TTAGGG Repeat Factors
    Trf1 Chip Qpcr
    Publish Year:2011
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