Despite the recovery of the left ventricular ejection fraction and the absence of major coronary artery disease, patients with takotsubo syndrome have outcomes that are considerably worse than the general population. 8–13 Takotsubo syndrome has an in-hospital mortality that is comparable to acute ST-segment–elevation myocardial infarction. 9–11, 13 Beyond the acute event, patients with takotsubo syndrome have a rate of all-cause death of 5.6% per patient-year and a rate of major adverse cardiac and cerebrovascular events of 9.9% per patient-year. 9

During long-term follow-up, the rate of major adverse cardiac and cerebrovascular events was 9.9% per patient-year, and the rate of death was 5.6% per patient-year. Conclusions Patients with takotsubo cardiomyopathy had a higher prevalence of neurologic or psychiatric disorders than did those with an acute coronary syndrome.