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- Effective immune responses in endometrial cancer are characterized by tumor-infiltrating B cells and plasma cells producing high levels of IgA antibodies. IgA binding to pIgR in endometrial tumor cells results in activation of proinflammatory and proapoptotic pathways and downregulation of DNA repair pathways.
aacrjournals.org/cancerres/article/82/5/766/681767/Beyond-T-Cells-IgA-Incites-I… - People also ask
WEBJun 2, 2021 · Endometrial cancer cells and tumor microenvironment are able to modulate the immune response. Among gynecological cancers, EC displays the highest overexpression of programmed cell death 1 (PD-1, CD279) and programmed cell death …
- Author: Sandrine Rousset-Rouviere, Philippe Rochigneux, Anne-Sophie Chrétien, Stéphane Fattori, Laurent Gorv...
- DOI: 10.3390/biomedicines9060632
- Publish Year: 2021
- Publication: Biomedicines. 2021 Jun; 9(6): 632.
Table - PMC - National Cent…
Endometrial cancer (EC) can easily be cured when diagnosed at an early …
Removal of homeostatic cyt…
Depletion of immune elements before adoptive cell transfer (ACT) can …
Immunotherapy in endom…
With the continuous elucidation of the pathogenesis of endometrial cancer, …
Importance of the endome…
This is an immunogenic cancer, with unique molecular subtypes associated with …
Beyond T Cells: IgA Incites I…
These findings highlight that coordinated B-cell and T-cell responses may predict …
Immune Environment and I…
1. Introduction. Gynecological cancers include ovarian, cervical, endometrial, …
The role and participation of …
Endometrial cancer (EC) is an immunogenic disease, and in recent years, …
Endometrial Cancer - StatP…
Objectives: Implement appropriate screening protocols for patients at …
Tumor immune microenviro…
Endometrial cancer of TMB-H, NSMP and TP53 mutant subtypes displayed …
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WEBImmunotherapy is treatment that helps the body's immune system attack cancer cells. Learn more about immunotherapy for endometrial cancer here.
- Studies of endometrial cancer tumor immunity
WEBJun 16, 2021 · Immune checkpoint inhibitors (ICIs), cancer vaccines, adoptive cell transfer (ACT), and lymphocyte-promoting cytokines are the main immunotherapy methods. …
WEBMay 10, 2024 · Our findings underscore a significant causal relationship between immunophenotypes and endometrial cancer in bidirectional MR analyses. Notably, the …
WEBDec 9, 2021 · This Primer by Makker and colleagues summarizes the epidemiology, pathophysiology, diagnosis and treatment of endometrial cancer.
WEBDec 2, 2015 · Existing evidence suggests that endometrial cancer is sufficiently immunogenic to be a reasonable candidate for active and/or passive immunotherapy.
WEBNov 1, 2023 · Endometrial cancer (EC) is an immunogenic disease, and in recent years, immunotherapy has shown benefit in the treatment of recurrent and advanced EC. This …
Immunotherapy for Uterine Cancer - Cancer Research …
WEBImmunomodulators. Dostarlimab (Jemperli): a checkpoint inhibitor that targets the PD-1 pathway; approved for subsets of patients with recurrent or advanced endometrial cancer with mismatch repair deficiency (dMMR)
Immunotherapy Treatment Landscape for Patients With …
WEBThe endometrial tumor immune microenvironment is complex and dynamic. Tumor-infiltrating lymphocytes (TILs) have been observed in endometrial cancer, the …
Endometrial Tumor Immune Response: Predictive Biomarker of …
WEBApr 15, 2019 · The tumor-specific immune response in endometrial cancer is variable within molecular subtypes. Thus, the tumor immune response offers a novel biomarker, …
Beyond T Cells: IgA Incites Immune Recognition in Endometrial …
WEBMar 3, 2022 · Effective immune responses in endometrial cancer are characterized by tumor-infiltrating B cells and plasma cells producing high levels of IgA antibodies. IgA …
Immune Environment and Immunotherapy in Endometrial …
WEBMar 29, 2023 · Immune Environment and Immunotherapy in Endometrial Carcinoma and Cervical Tumors. by. Alexandra Lainé. 1,*,†, Andrea M. Gonzalez-Lopez. 2,†, Uzma …
Tumor mutation burden in connection with immune-related …
WEBJan 28, 2021 · Uterine corpus endometrial carcinoma (UCEC) is a common type of gynecological tumor. It is estimated that there will be 65,620 new cases and 12,590 …
The roles and therapeutic applications of cytokines in endometrial …
WEBAug 1, 2022 · Endometrial cancer (EC) is a common gynecological cancer that affects both postmenopausal and fertile women. The average age of EC patients is decreasing, …
Uterine Cancer & Endometrial Cancer Chemotherapy
WEBImmunotherapy for uterine and endometrial cancer. Cancer specialists at Penn Medicine are pioneers in using a patient's own immune system to fight cancer. …
Prediction of recurrence risk in endometrial cancer with ... - Nature
WEBMay 24, 2024 · EC is the most common gynecological malignancy in high-income countries and is increasing in incidence 1. Although most women with localized disease are cured …
LORIS robustly predicts patient outcomes with immune ... - Nature
WEBJun 3, 2024 · The Pradat et al. cohort comprised 1,031 participants with different types of cancer; a total of 57 participants from 13 solid tumor types were included in this study …
Identification of the role of endoplasmic reticulum stress genes in ...
WEBOct 25, 2023 · Identification of the role of endoplasmic reticulum stress genes in endometrial cancer and their association with tumor immunity. Tang ansu Zhang, …
Insights into the prognostic value and immunological role of CD74 …
WEB16 hours ago · Background CD74 is a non-polymorphic type II transmembrane glycoprotein. It is involved in the regulation of T and B cell development, and dendritic cell (DC) …
Hormonal Therapies for Endometrial Cancer in the Molecular Era
WEB3 days ago · Grade 1 endometrioid endometrial cancer typically tends to be estrogen receptor positive and thus have a higher responsiveness to hormonal therapy, noted …
Mesenchymal stromal cells equipped by IFNα empower T cells
WEBCancer treatments have been revolutionized by the emergence of immune checkpoint blockade therapies. However, only a minority of patients with various tumor types have …
Targeting FGFR for cancer therapy - Journal of Hematology
WEBJun 3, 2024 · FGFR amplification in tumors. The phenomenon of increased copy number of the FGFR gene in cells is called gene amplification. A genetic sequencing of more than …
Inhibition of epigenetic control enzymes in immune cells
WEB2 days ago · Immunotherapy is one of the pillars in the fight against cancer and aims to enable the body's own immune system to fight a tumor. A recent study now shows that …
Cleveland Clinic Research Findings May Improve Chemotherapy …
WEB1 day ago · Currently the CD55 protein is difficult to target because of its protective role in the immune system and its location on the cell surface. Ofer Reizes, Ph.D ., the Laura …
Circadian control of tumor immunosuppression affects efficacy
WEBMay 28, 2024 · The circadian clock is a critical regulator of immunity, and this circadian control of immune modulation has an essential function in host defense and tumor …
Tumors Hijack a Brain-Enriched Metabolite to Evade Antitumor …
WEB16 hours ago · Major Finding: HER2+ breast tumor cells release N-acetylaspartate (NAA) to inhibit immunological synapse formation. Concept: NAA protects neurons from …
Cancer: Symptoms, Causes, Treatment, Stages, Prevention
WEBOct 28, 2023 · Cancer is the uncontrolled growth of abnormal cells anywhere in a body. These abnorm al cells are termed cancer cells, malignant cells, or tumor cells. These …
New findings may lead to improved treatments for chemotherapy …
WEB19 hours ago · Cleveland Clinic researchers have discovered a new location for a protein that helps ovarian cancer cells resist chemotherapy treatments and that fosters …
What is a tumor? What you need to know about cancer and …
WEB2 days ago · The first thing to understand is that tumors start as clumps of cells "that begin to grow abnormally to form a mass," says Dr. Julie Gralow, the chief medical officer at …
GDC Data Portal Homepage
WEBMar 29, 2024 · Harmonized clinical and genomic data allow for convenient cross-analysis and comparison. Clinical data, including demographics, diagnosis and treatment …
Tumor-associated macrophages restrict CD8 - Nature
WEBJun 3, 2024 · Weaver and colleagues show that TGFβ-induced collagen deposition and metabolic reprogramming of the breast cancer microenvironment by tumor-associated …
New glioblastoma treatment reaches human brain tumor and
WEB2 days ago · An immune checkpoint blockade antibody blocks the deactivation of the immune system by the cancer cells. The immune system has built-in brakes -- called …
An mRNA Melanoma Vaccine Shows Promise | TIME
WEBJun 3, 2024 · In the phase 2 study of patients with stage 3 or stage 4 melanoma who were treated after surgery to remove the bulk of their tumors, two thirds received a monthly …
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