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Engineering adeno-associated viral vectors to evade innate …
WEBFeb 2, 2021 · To engineer scAAV.FIX, sequences were inserted into the unique KpnI site found immediately 5’ of the transthyretin promoter. 3 copies of ODN TTAGGG (TTTAGGGTTAGGGTTAGGGTTAGGG) were inserted, separated by AAAAA linkers …
- Author: Ying Kai Chan, Ying Kai Chan, Sean K. Wang, Colin J. Chu, David A. Copland, Alexander J. Letizia, Al...
- DOI: 10.1126/scitranslmed.abd3438
- Publish Year: 2021
- Published: 2021/02/02
See results only from ncbi.nlm.nih.govFigure 1
Nucleic acids are utilized in many therapeutic modalities, including gene …
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Nucleic acids are utilized in many therapeutic modalities, including gene …
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Introduction. Species can be divided into altricial (helpless) and precocial (freely …
Iodoacetic Acid, But Not So…
Our purpose was to find a method to create a large animal model of inducible …
Assessment and In Vivo Sc…
Figure S4: A worked example of the scoring system using the image acquisition …
Generation of an Inbred Mini…
Generation of an Inbred Miniature Pig Model of Retinitis Pigmentosa - …
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A151, the archetypal example of a chemically synthesized suppressive …
A suppressive oligodeoxynucleotide expressing TTAGGG motifs …
WEBJan 9, 2020 · A151, the archetypal example of a chemically synthesized suppressive oligodeoxynucleotide (ODN) based on repetitive telomere-derived TTAGGG …
A suppressive oligodeoxynucleotide expressing TTAGGG motifs …
WEBOct 21, 2019 · A151, the archetypal example of a chemically synthesized suppressive oligodeoxynucleotide (ODN) based on repetitive telomere-derived TTAGGG …
- Studies of ttaggg sequence and inflammation
Engineering adeno-associated viral vectors to evade innate
WEBTo engineer scAAV.FIX, sequences were inserted into the unique Kpn I site found immediately 5′ of the transthyretin promoter. Three copies of ODN TTAGGG …
Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive …
WEBOct 1, 2013 · Importantly, certain DNA sequences such as the TTAGGG repeat commonly found in mammalian telomeric DNA can serve to suppress innate immune activation. …
WEBand TTAGGG only inhibited ~35% of induced NF- B response (fig. S1D). Thus, incorporation of a TLR9i sequence within the same molecule as an inflammatory DNA …
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+3 more answersmicrosoftstart.msn.com Synthetic Oligodeoxynucleotides Containing …
WEBOct 1, 2013 · Synthetic oligodeoxynucleotides (ODNs) comprised of the immunosuppressive motif TTAGGG block TLR9 signaling, prevent STAT1 and STAT4 phosphorylation and attenuate a variety of inflammatory …
Suppressive oligodeoxynucleotides containing TTAGGG motifs …
WEBSuppressive oligodeoxynucleotides (ODN) containing repetitive TTAGGG motifs present in mammalian telomeres have proven useful in the treatment of autoimmune diseases …
Structure, mechanism and therapeutic utility of …
WEBMar 1, 2016 · Synthetic oligodeoxynucleotides that can down-regulate cellular elements of the immune system have been developed and are being widely studied in preclinical …
Inhibition of cGAS–STING pathway alleviates ... - Nature
WEBSep 19, 2023 · Article. Open access. Published: 19 September 2023. Inhibition of cGAS–STING pathway alleviates neuroinflammation-induced retinal ganglion cell …
WEBTLR9i sequences have been tested extensively in the literature as a standalone agent co-administered with inflammatory DNA ligands, but this strategy likely requires a large …
A highly conserved repetitive DNA sequence, (TTAGGG)n, …
WEBA highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library. Quantitative hybridization to chromosomes …
WEBto the long-range organization of chromosomes and gene regulation networks by binding to extratelomeric sequences. Keywords: telomere; TRF1; TRF2; interstitial telomeric …
Suppressive oligodeoxynucleotides containing TTAGGG motifs …
WEBSuppressive oligodeoxynucleotides (ODN) containing repetitive TTAGGG motifs present in mammalian telomeres have proven useful in the treatment of autoimmune diseases …
Telomere attrition and inflammation: the chicken and the egg …
WEBOpen access. Published: 28 August 2022. Telomere attrition and inflammation: the chicken and the egg story. J. P. Shirley Niveta, M. Anup Kumar & Venkatachalam …
IJMS | Free Full-Text | Molecular Aspects of Senescence and
WEBNov 30, 2020 · Senescence is a process characterised by a stable proliferative arrest. Sometimes it can be beneficial—for example, it can suppress tumour development or …
A highly conserved repetitive DNA sequence, (TTAGGG)n, …
WEBA highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library. Quantitative hybridization to chromosomes …
The human TTAGGG repeat factors 1 and 2 bind to a subset of
WEBMar 22, 2011 · Original Article. Published: 22 March 2011. The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats. …
Conservation of the human telomere sequence (TTAGGG)n …
WEBAbstract. To determine the evolutionary origin of the human telomere sequence (TTAGGG)n, biotinylated oligodeoxynucleotides of this sequence were hybridized to …
Synthetic Oligodeoxynucleotides Containing Multiple Telemeric …
WEBOct 16, 2015 · Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and …
Conservation of (TTAGG)n Telomeric Sequences Among Ants …
WEBJul 1, 2002 · PDF. Split View. Cite. Permissions. Share. Abstract. To determine the telomere sequence in Tapinoma nigerrimum, we carried out in situ hybridization using TTAGGG …
Molecular mechanisms of aging and anti-aging strategies
WEBMay 24, 2024 · The continuous accumulation of DNA-damaged cells triggers cell death and senescence, ultimately leading to chronic inflammation, loss of function, atrophy, and …
Physical mapping of rDNA genes, ( TTAGGG )n telomeric …
WEBSep 1, 2000 · Physical mapping of rDNA genes, ( TTAGGG )n telomeric sequence and other karyological features in two earthworms of the family Lumbricidae (Annelida: …
Conservation of the human telomere sequence (TTAGGG)n …
WEBThe conservation of the (TTAGGG)n sequence and its telomeric location, in species thought to share a common ancestor over 400 million years ago, strongly suggest that …
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