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Telomeres and telomerase (article) | Khan Academy
Learn about telomeres, the protective DNA sequences at the ends of eukaryotic chromosomes, and telomerase, the enzyme that can extend them. Find out how telomeres shorten with age and how they are related to cancer. See more
Telomeres as protective "caps" on the tips of eukaryotic chromosomes. How telomerase extends telomeres. See more
- If you could zoom in and look at the DNA on the tip of one of your chromosomes, …
- Repetitive regions at the very ends of chromosomes are call… See more
- Unlike bacterial chromosomes, the chromosomes of eukaryotes are linear (rod-shaped), meaning that they have e…
- Why is this the case? When DNA is being copied, one of the two new strands of DNA at a replication fork is … See more
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A highly conserved repetitive DNA sequence, (TTAGGG)n, …
WEBA highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library. Quantitative hybridization to chromosomes …
- Author: R. K. Moyzis, J. M. Buckingham, L. S. Cram, M. Dani, L. L. Deaven, M. D. Jones, J. Meyne, R. L. Ratl...
- Publish Year: 1988
Telomere - Wikipedia
During DNA replication, DNA polymerase cannot replicate the sequences present at the 3' ends of the parent strands. This is a consequence of its unidirectional mode of DNA synthesis: it can only attach new nucleotides to an existing 3'-end (that is, synthesis progresses 5'-3') and thus it requires a primer to initiate replication. On the leading strand (oriented 5'-3' within the replication fork), D…
Wikipedia · Text under CC-BY-SA license- Studies of ttaggg
The human TTAGGG repeat factors 1 and 2 bind to a …
WEBMar 22, 2011 · The TTAGGG DNA repeat proteins 1 and 2 (TRF1 and TRF2) bind to mammalian telomeres as part of the shelterin complex and are essential for maintaining chromosome end stability.
Telomeres of Human Chromosomes | Learn Science at Scitable
WEBLearn about the structure and function of telomeres, the DNA sequences that cap the ends of chromosomes and protect them from fusion. Find out how telomeres are formed, …
CST–polymerase α-primase solves a second telomere end
WEBFeb 28, 2024 · For PCR assay with synthetic telomeric oligonucleotides [TTAGGG] 5–20 –TTAG-[A] 10, 20 pM single strand oligonucleotide DNA was used for primer extension. …
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Conservation of the human telomere sequence (TTAGGG)n …
WEBThe conservation of the (TTAGGG)n sequence and its telomeric location, in species thought to share a common ancestor over 400 million years ago, strongly suggest that this …
Telomeres: Structure and Function | SpringerLink
WEBMar 22, 2023 · Human telomeric DNA is composed of tandem repeats of the sequence 5′- (TTAGGG) n -3′ and is complexed with sequence-specific DNA binding proteins, forming …
The DNA secondary structures at telomeres and genome instability
WEBMar 26, 2020 · Telomeric DNA are TTAGGG tandem repeats, which are susceptible for oxidative DNA damage and hotspot regions for formation of DNA secondary structures …
The Human Telomere Sequence, (TTAGGG)4, in the Absence …
WEBJan 6, 2014 · The increasing interest in studying biomolecules under more cellular-like conditions prompted us to investigate the effect of osmotic stress on the structural and …
At the Beginning of the End and in the Middle of the Beginning ...
WEBFeb 5, 2019 · TTAGGG repeats are the building blocks of telomeres in some invertebrates, including Lepidoptera species and flat worms Mollusca and Annelida . This motif is also …
The human TTAGGG repeat factors 1 and 2 bind to a subset of
WEBThe TTAGGG DNA repeat proteins 1 and 2 (TRF1 and TRF2) bind to mammalian telomeres as part of the shelterin complex and are essential for maintaining chromosome end stability.
Telomerase - Wikipedia
WEBTelomerase, also called terminal transferase, [1] is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres. A telomere is a region …
Telomeric Localization of the Vertebrate-type Hexamer Repeat, …
WEBThe hexamer repeat sequence (TTAGGG) n, found at the ends of all vertebrate chromosomes, was previously identified as the main building element of one member of …
The ALT pathway generates telomere fusions that can be
WEBJan 2, 2024 · Telomeres are nucleoprotein complexes composed of telomeric TTAGGG repeats and telomere binding proteins that prevent the recognition of chromosome ends …
G-quadruplex formation in human telomeric (TTAGGG)
WEBMay 8, 2007 · The PEG-induced formation of quadruplex in G4C4 should liberate the C-rich strand from base paring with the G-rich strand. This expected outcome was examined …
Telomere-binding protein - Wikipedia
WEBTelomere-binding proteins (also known as TERF, TRBF, TRF) function to bind telomeric DNA in various species. In particular, telomere-binding protein refers to TTAGGG repeat …
Telomere Testing (TeloYears) - Dr. John Westerdahl
WEBTechnically speaking, telomeres are repetitive stretches of the nucleotide base pair sequence TTAGGG at the ends of our chromosomes. When we are born, our telomeres …
A mammalian factor that binds telomeric TTAGGG repeats in vitro.
WEBWe have identified a DNA-binding activity with specificity for the TTAGGG repeat arrays found at mammalian telomeres. This factor, called TTAGGG repeat factor (TRF), is …
(TTAGGG)n telomeric sequence in selachian chromosomes
WEBNov 1, 2001 · The distribution of telomeric sequence (TTAGGG) n in the genomes of Chondrichthian species at different stages of evolution was investigated both by DNA …
Suman Kalyan Pradhan, Ph.D. - Turnstone Biologics | LinkedIn
WEBJul 15, 2017 · Human telomere d[(TTAGGG)4] undergoes a conformational transition to the Na+-form upon binding with sanguinarine in presence of K+ Biochemical and …
Physical mapping of rDNA genes, (TTAGGG) - Nature
WEBSep 1, 2000 · The telomeric sequence (TTAGGG) n hybridized with termini of all the chromosomes in both earthworms. Flow cytometry DNA assays showed that O. …
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