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  2. Studies of ttaggg sequence and inflammation
    PubMed
    A suppressive oligodeoxynucleotide expressing TTAGGG motifs modulates cellular energetics through the mTOR signaling pathway
    Immune-mediated inflammation must be down-regulated to facilitate tissue remodeling during homeostatic restoration of an inflammatory response. Uncontrolled or over-exuberant immune activation can cause autoimmune diseases, as well as tissue destruction.
    Author: Volkan Yazar
    Published: 2020/01/09
    Keywords: A151 ODN…
    National Center for Biotechnology Information
    A suppressive oligodeoxynucleotide expressing TTAGGG motifs modulates cellular energetics through the mTOR signaling pathway
    The immunosuppressive ODN A151 profoundly affects mTOR signaling Keywords: A151 ODN, immunometabolism, immunosuppression, microarray
    Author: Volkan Yazar, …
    Published: 2020/01
    Publication: Int Immun…
    National Center for Biotechnology Information
    Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive TTAGGG Motifs Inhibit AIM2 Inflammasome Activation
    Synthetic oligodeoxynucleotides comprised of the immunosuppressive motif TTAGGG block TLR9 signaling, prevent STAT1 and STAT4 phosphorylation and attenuate a variety of inflammatory responses in vivo. Here, we demonstrate that such suppressive oligodeoxynucleotides
    Author: John J. Kamin…
    Published: 2013/10/10
    DOI: 10.4049/jimmunol.…
    PubMed
    Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes
    Type I interferon (IFN) is a critical mediator of autoimmune diseases such as systemic lupus erythematosus (SLE) and Aicardi-Goutières Syndrome (AGS). The recently discovered cyclic-GMP-AMP (cGAMP) synthase (cGAS) induces the production of type I IFN
    Author: Folkert Steinh…
    Published: 2018/4
    Keywords: Autoimmun…
    ScienceDirect
    Invited review Structure, mechanism and therapeutic utility of immunosuppressive oligonucleotides
    Synthetic oligodeoxynucleotides that can down-regulate cellular elements of the immune system have been developed and are being widely studied in preclinical models. These agents vary in sequence, mechanism of action, and cellular target(s) but share
    Published: 2016/03/01
    Cited By: 26
    Page Count: 10
    National Center for Biotechnology Information
    Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes
    The recognition of microbial DNA is a major mechanism by which the immune system detects pathogens. Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that activates innate immune responses through production of the second messenger cGAMP,
    Author: Folkert Steinh…
    Published: 2018/04
    DOI: 10.1002/eji.20174…
    National Center for Biotechnology Information
    Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats
    The immune system plays a fundamental role in both the development and pathobiology of stroke. Inflammasomes are multiprotein complexes that have come to be recognized as critical players in the inflammation that ultimately contributes to stroke severity.
    Author: Jing Zhao, Yo…
    Published: 2015
    Publication: PLoS On…
    PubMed
    A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
    A highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library. Quantitative hybridization to chromosomes sorted by flow cytometry indicates that comparable amounts of this sequence are present
    Author: R K Moyzis
    Published: 1988/9
    Keywords: National In…
    National Center for Biotechnology Information
    Conservation of the human telomere sequence (TTAGGG)n among vertebrates.
    To determine the evolutionary origin of the human telomere sequence (TTAGGG)n, biotinylated oligodeoxynucleotides of this sequence were hybridized to metaphase spreads from 91 different species, including representative orders of bony fish, reptiles,
    Author: J Meyne, R L …
    Published: 1989/09
    Publication: Proc Natl …
     
  3. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409505

    Engineering adeno-associated viral vectors to evade innate …

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      Nucleic acids are utilized in many therapeutic modalities, including gene …

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      Nucleic acids are utilized in many therapeutic modalities, including gene …

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      Introduction. Species can be divided into altricial (helpless) and precocial (freely …

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  4. PubMed
    https://pubmed.ncbi.nlm.nih.gov/31633763

    A suppressive oligodeoxynucleotide expressing TTAGGG motifs …

    Tags:
    Odn A151
    Publish Year:2020
    Immune System
  5. People also ask
    Do TTAGGG proteins bind to nontelomeric DNA sequences?However, very little is known on the binding of these proteins to nontelomeric DNA sequences. The TTAGGG DNA repeat proteins 1 and 2 (TRF1 and TRF2) bind to mammalian telomeres as part of the shelterin complex and are essential for maintaining chromosome end stability.

    The human TTAGGG repeat factors 1 and 2 bind to a subset of ... - Natu…

    nature.com
    What causes elevated TTG?

    Dr. Howard E. LeWine

    M.D. Chief Medical Editor, Harvard Health Publishing · 40 years of exp

    An elevated blood level of TTG (tissue transglutaminase) supports a diagnosis of celiac disease. Celiac disease (also called gluten-sensitive enteropathy) is an intestinal disorder in which the body cannot tolerate gluten. Gluten is a natural protein in many grains, including wheat, barley, rye and oats. People with celiac disease have an immune reaction that is triggered by gluten. The immune reaction causes inflammation at the surface of the small intestine where it damages the surface of the intestine. When they are damaged, the intestine cannot absorb nutrients properly.
    +3 more answers
    microsoftstart.msn.com
    Does TTAGGG suppress CpG-induced TLR9 phosphorylation?Data are presented as mean ± SD from three biological replicates representative of three experiments. Previous studies have shown that the deoxyguanosine residues found within A151’s TTAGGG motif play a role in suppression of CpG-induced TLR9 signaling as well as STAT1 and STAT4 phosphorylation.

    Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive TTAGGG

    ncbi.nlm.nih.gov
    What does TTAGGG stand for?A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. A highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library.

    A highly conserved repetitive DNA sequence, (TTAGGG)n, present at th…

    pnas.org
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  6. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185194

    A suppressive oligodeoxynucleotide expressing TTAGGG motifs …

  7. Science | AAAS
    https://www.science.org/doi/10.1126/scitranslmed.abd3438

    Engineering adeno-associated viral vectors to evade innate

    Tags:
    Viral Vectors
    Publish Year:2021
    Adenovirus Vector Production Titer
  8. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878640

    Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive …

    Tags:
    Publish Year:2013
    10.4049/jimmunol.1300530
    Published:2013/10/10
  9. Science | AAAS
    https://www.science.org/doi/pdf/10.1126/...
    [PDF]

    GENE THERAPY Engineering adeno-associated viral …

    Tags:
    Viral Vectors
    Inflammation
  10. PubMed
    https://pubmed.ncbi.nlm.nih.gov/29215161

    Suppressive oligodeoxynucleotides containing TTAGGG motifs …

    Tags:
    Publish Year:2018
  11. ScienceDirect
    https://www.sciencedirect.com/science/article/abs/...

    Structure, mechanism and therapeutic utility of …

    Tags:
    Immune System
    Publish Year:2016
  12. American Association of Immunologists
    https://journals.aai.org/jimmunol/article/…

    Synthetic Oligodeoxynucleotides Containing …

    WebOct 1, 2013 · Synthetic oligodeoxynucleotides (ODNs) comprised of the immunosuppressive motif TTAGGG block TLR9 signaling, prevent STAT1 and STAT4 phosphorylation and attenuate a variety of inflammatory …

    Tags:
    TTAGGG
    TLR9
  13. UCL Discovery
    https://discovery.ucl.ac.uk/id/eprint/10121916/31/Dick_Main Text Final.pdf
    [PDF]

    Engineering adeno-associated viral vectors to evade innate …

    Tags:
    Viral Vectors
    DNA
  14. Nature
    https://www.nature.com/articles/cr201140

    The human TTAGGG repeat factors 1 and 2 bind to a …

    WebMar 22, 2011 · Original Article. Published: 22 March 2011. The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats. Thomas Simonet, Laure-Emmanuelle...

    Missing:

    • inflammation

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    Tags:
    TTAGGG Repeat Factors
    Publish Year:2011
    Ttaggg Repeats in What Cell
  15. Nature
    https://www.nature.com/articles/s41419-023-06140-0

    Inhibition of cGAS–STING pathway alleviates ... - Nature

  16. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386451

    Suppressive oligodeoxynucleotides containing TTAGGG motifs …

    Tags:
    Publish Year:2018
    Published:2018/04
  17. Oxford Academic
    https://academic.oup.com/intimm/article/32/1/39/5601533

    suppressive oligodeoxynucleotide expressing TTAGGG motifs …

    Tags:
    Publish Year:2020
    Odn A151
  18. PNAS
    https://www.pnas.org/doi/10.1073/pnas.85.18.6622

    A highly conserved repetitive DNA sequence, (TTAGGG)n, …

    Tags:
    Conserved Dna Sequence
    Highly Repetitive Sequence
    Repetitive DNA
  19. springeropen.com
    https://jmhg.springeropen.com/articles/10.1186/s43042-022-00335-4

    Telomere attrition and inflammation: the chicken and the egg …

  20. Oxford Academic
    https://academic.oup.com/jhered/article/93/4/282/2187315

    Conservation of (TTAGG)n Telomeric Sequences Among Ants …

    Tags:
    P. Lorite, J. A. Carrillo, T. Palomeque
    Publish Year:2002
  21. Nature
    https://www.nature.com/articles/cr201140.pdf
    [PDF]

    The human TTAGGG repeat factors 1 and 2 bind to a subset …

    Tags:
    Publish Year:2011
    TTAGGG Repeat Factors
  22. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608557

    Synthetic Oligodeoxynucleotides Containing Multiple Telemeric …

    Tags:
    Publish Year:2015
    10.1371/journal.pone.0140772
    Published:2015
  23. Nature
    https://www.nature.com/articles/6887090

    Physical mapping of rDNA genes, ( TTAGGG )n telomeric …

    Tags:
    Roberto Vitturi, Maria Stella Colomba, Anna Pirrone, Angelo Libertini
    Publish Year:2000
  24. PubMed
    https://pubmed.ncbi.nlm.nih.gov/3413114

    A highly conserved repetitive DNA sequence, (TTAGGG)n, …

    Tags:
    Conserved Dna Sequence
    Highly Repetitive Sequence
    Human Telomere Ttaggg
  25. Genome Medicine
    https://genomemedicine.biomedcentral.com/articles/...

    The landscape of rare genetic variation associated with …

  26. PubMed
    https://pubmed.ncbi.nlm.nih.gov/34597122

    Tregs and inflammation-bring it on! - PubMed

    Tags:
    Publish Year:2021
    Victoire Gouirand, Michael D. Rosenblum
  27. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC297991

    Conservation of the human telomere sequence (TTAGGG)n …

    Tags:
    Human Telomere Ttaggg
    Publish Year:1989

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