ttaggg sequence and inflammation - Search
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  1. Bokep

    https://viralbokep.com/viral+bokep+terbaru+2021&FORM=R5FD6

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  2. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409505

    Engineering adeno-associated viral vectors to evade innate …

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      Nucleic acids are utilized in many therapeutic modalities, including gene …

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      Nucleic acids are utilized in many therapeutic modalities, including gene …

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      Introduction. Species can be divided into altricial (helpless) and precocial (freely …

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  3. Nature
    https://www.nature.com/articles/s41467-024-49072-9

    A persistent variant telomere sequence in a human pedigree

    Tags:
    Conserved Dna Sequence
    TTAGGG
  4. PubMed
    https://pubmed.ncbi.nlm.nih.gov/31633763

    A suppressive oligodeoxynucleotide expressing TTAGGG motifs …

  5. Studies of ttaggg sequence and inflammation
    PubMed
    A suppressive oligodeoxynucleotide expressing TTAGGG motifs modulates cellular energetics through the mTOR signaling pathway
    Immune-mediated inflammation must be down-regulated to facilitate tissue remodeling during homeostatic restoration of an inflammatory response. Uncontrolled or over-exuberant immune activation can cause autoimmune diseases, as well as tissue destruction.
    Author: Volkan Yazar
    Published: 2020/01/09
    Keywords: A151 ODN…
    National Center for Biotechnology Information
    A suppressive oligodeoxynucleotide expressing TTAGGG motifs modulates cellular energetics through the mTOR signaling pathway
    The immunosuppressive ODN A151 profoundly affects mTOR signaling Keywords: A151 ODN, immunometabolism, immunosuppression, microarray
    Author: Volkan Yazar, …
    Published: 2020/01
    Publication: Int Immun…
    National Center for Biotechnology Information
    Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes
    The recognition of microbial DNA is a major mechanism by which the immune system detects pathogens. Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that activates innate immune responses through production of the second messenger cGAMP,
    Author: Folkert Steinh…
    Published: 2018/04
    DOI: 10.1002/eji.20174…
    ScienceDirect
    Invited review Structure, mechanism and therapeutic utility of immunosuppressive oligonucleotides
    Synthetic oligodeoxynucleotides that can down-regulate cellular elements of the immune system have been developed and are being widely studied in preclinical models. These agents vary in sequence, mechanism of action, and cellular target(s) but share
    Published: 2016/03/01
    Cited By: 26
    Page Count: 10
    PubMed
    Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes
    Type I interferon (IFN) is a critical mediator of autoimmune diseases such as systemic lupus erythematosus (SLE) and Aicardi-Goutières Syndrome (AGS). The recently discovered cyclic-GMP-AMP (cGAMP) synthase (cGAS) induces the production of type I IFN
    Author: Folkert Steinh…
    Published: 2018/4
    Keywords: Autoimmun…
    National Center for Biotechnology Information
    Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive TTAGGG Motifs Inhibit AIM2 Inflammasome Activation
    Synthetic oligodeoxynucleotides comprised of the immunosuppressive motif TTAGGG block TLR9 signaling, prevent STAT1 and STAT4 phosphorylation and attenuate a variety of inflammatory responses in vivo. Here, we demonstrate that such suppressive oligodeoxynucleotides
    Author: John J. Kamin…
    Published: 2013/10/10
    DOI: 10.4049/jimmunol.…
    PubMed
    A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
    A highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library. Quantitative hybridization to chromosomes sorted by flow cytometry indicates that comparable amounts of this sequence are present
    Author: R K Moyzis
    Published: 1988/9
    Keywords: National In…
    PubMed
    Telomere shortening during aging: Attenuation by antioxidants and anti-inflammatory agents
    Telomeres are a repeated sequence -of bases found at the ends of chromosomes. In humans, this sequence is TTAGGG, which is repeated over 2000 times. Telomeres protect the ends chromosomes from fusion with nearby chromosomes, and allow effective replication
    Author: Kedar N Prasad
    Published: 2017/6
    Keywords: Aging; Anti …
    National Center for Biotechnology Information
    Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats
    The immune system plays a fundamental role in both the development and pathobiology of stroke. Inflammasomes are multiprotein complexes that have come to be recognized as critical players in the inflammation that ultimately contributes to stroke severity.
    Author: Jing Zhao, Yo…
    Published: 2015
    Publication: PLoS On…
    National Center for Biotechnology Information
    The Human Telomere Sequence, (TTAGGG)4, in the Absence and Presence of Cosolutes: A Spectroscopic Investigation
    Historically, biophysical studies of nucleic acids have been carried out under near ideal conditions, i.e., low buffer concentration (e.g., 10 mM phosphate), pH 7, low ionic strength (e.g., 100 mM) and, for optical studies, low concentrations of DNA (e.g.,
    Author: Vishal R. Shar…
    Published: 2014/01
    Publication: Molecules…
    National Center for Biotechnology Information
    Conservation of the human telomere sequence (TTAGGG)n among vertebrates.
    To determine the evolutionary origin of the human telomere sequence (TTAGGG)n, biotinylated oligodeoxynucleotides of this sequence were hybridized to metaphase spreads from 91 different species, including representative orders of bony fish, reptiles,
    Author: J Meyne, R L …
    Published: 1989/09
    Publication: Proc Natl …
  6. Science | AAAS
    https://www.science.org/doi/10.1126/scitranslmed.abd3438

    Engineering adeno-associated viral vectors to evade innate

    Tags:
    Viral Vectors
    Publish Year:2021
    Adenovirus Vector Production Titer
  7. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185194

    A suppressive oligodeoxynucleotide expressing TTAGGG motifs …

    Tags:
    Odn A151
    Publish Year:2020
    10.1093/intimm/dxz059
  8. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386451

    Suppressive oligodeoxynucleotides containing TTAGGG motifs …

    Tags:
    Odn A151
    Repetitive DNA
    Publish Year:2018
    Published:2018/04
  9. People also ask
    What does TTAGGG stand for?A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. A highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library.

    A highly conserved repetitive DNA sequence, (TTAGGG)n, present at th…

    pnas.org
    Do TTAGGG proteins bind to nontelomeric DNA sequences?However, very little is known on the binding of these proteins to nontelomeric DNA sequences. The TTAGGG DNA repeat proteins 1 and 2 (TRF1 and TRF2) bind to mammalian telomeres as part of the shelterin complex and are essential for maintaining chromosome end stability.

    The human TTAGGG repeat factors 1 and 2 bind to a subset of ... - Natu…

    nature.com
    Does TDAG8 stimulate inflammatory cytokines?TDAG8 stimulation by H + also enhances secretion of anti-inflammatory cytokines while reducing proinflammatory signals. AA, arachidonic acid; FA, fatty acids; TAG, triacylglycerol. b, When TDAG8 activity is reduced, impaired lysosomal activity in dendritic cells increases antigen presentation and secretion of IL-12 and IL-23.

    When inflammation turns sour on T cells | Nature Immunology

    nature.com
    Does ODN TTAGGG inhibit the activation of TLR7 and TLR2/6?ODN TTAGGG, a well-known TLR9i sequence derived from mammalian telomeres ( 23 ), did not inhibit the activation of TLR7 or TLR2/6 (sensors of microbial RNA and lipoproteins, respectively) even at high concentration, supporting its specificity for TLR9 ( fig. S1E and S1F ).

    Engineering adeno-associated viral vectors to evade innate immune an…

    ncbi.nlm.nih.gov
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  10. Science | AAAS
    https://www.science.org/doi/pdf/10.1126/...
    [PDF]

    GENE THERAPY Engineering adeno-associated viral …

    Tags:
    Viral Vectors
    Inflammation
  11. PNAS
    https://www.pnas.org/doi/10.1073/pnas.85.18.6622

    A highly conserved repetitive DNA sequence, (TTAGGG)n, …

    Tags:
    Repetitive DNA
    Conserved Dna Sequence
    Highly Repetitive Sequence
  12. ScienceDirect
    https://www.sciencedirect.com/science/article/abs/...

    Structure, mechanism and therapeutic utility of …

    Tags:
    Defne Bayik, Ihsan Gursel, Dennis M. Klinman
    Publish Year:2016
  13. PubMed
    https://pubmed.ncbi.nlm.nih.gov/29215161

    Suppressive oligodeoxynucleotides containing TTAGGG motifs …

    Tags:
    Odn A151
    Repetitive DNA
    Publish Year:2018
  14. American Association of Immunologists
    https://journals.aai.org/jimmunol/article/191/7/...

    Synthetic Oligodeoxynucleotides Containing Suppressive …

    Tags:
    TTAGGG
    TLR9
  15. Nature
    https://www.nature.com/articles/s41419-023-06140-0

    Inhibition of cGAS–STING pathway alleviates ... - Nature

  16. Nature
    https://www.nature.com/articles/cr201140

    The human TTAGGG repeat factors 1 and 2 bind to a subset of

    Tags:
    TTAGGG Repeat Factors
    Publish Year:2011
    Ttaggg Repeats in What Cell
  17. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878640

    Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive …

    Tags:
    Publish Year:2013
    10.4049/jimmunol.1300530
    Published:2013/10/10
  18. Oxford Academic
    https://academic.oup.com/jhered/article/93/4/282/2187315

    Conservation of (TTAGG)n Telomeric Sequences Among Ants …

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    P. Lorite, J. A. Carrillo, T. Palomeque
    Publish Year:2002
  19. springeropen.com
    https://jmhg.springeropen.com/articles/10.1186/s43042-022-00335-4

    Telomere attrition and inflammation: the chicken and the egg …

    Tags:
    Human Telomere Ttaggg
    Telomere Attrition and Inflammation
  20. PubMed
    https://pubmed.ncbi.nlm.nih.gov/3413114

    A highly conserved repetitive DNA sequence, (TTAGGG)n, …

    Tags:
    Human Telomere Ttaggg
    Repetitive DNA
    Conserved Dna Sequence
  21. PubMed
    https://pubmed.ncbi.nlm.nih.gov/28431907

    Telomere shortening during aging: Attenuation by antioxidants

    Tags:
    Kedar N. Prasad, Meixia Wu, Stephen C. Bondy
    Publish Year:2017
  22. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608557

    Synthetic Oligodeoxynucleotides Containing Multiple Telemeric …

    Tags:
    Publish Year:2015
    10.1371/journal.pone.0140772
    Published:2015
  23. Nature
    https://www.nature.com/articles/cr201140.pdf
    [PDF]

    The human TTAGGG repeat factors 1 and 2 bind to a subset …

    Tags:
    Publish Year:2011
    TTAGGG Repeat Factors
  24. harvard.edu
    https://news.harvard.edu/gazette/story/2024/06/a...

    A photographer’s love letter to ‘Vision and Justice’ course — …

  25. Nature
    https://www.nature.com/articles/s41590-022-01241-y

    When inflammation turns sour on T cells | Nature Immunology

    Tags:
    OGR1
    TDAG8
  26. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271192

    The Human Telomere Sequence, (TTAGGG)4, in the Absence …

    Tags:
    Human Telomere Ttaggg
    Vishal R Sharma, Richard D Sheardy
  27. harvard.edu
    https://news.harvard.edu/gazette/story/2024/05/...

    Harvard-led study IDs statin that may block pathway to some …

  28. Nature
    https://www.nature.com/articles/6887090

    Physical mapping of rDNA genes, ( TTAGGG )n telomeric …

    Tags:
    Roberto Vitturi, Maria Stella Colomba, Anna Pirrone, Angelo Libertini
    Publish Year:2000
  29. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC297991

    Conservation of the human telomere sequence (TTAGGG)n …

    Tags:
    Human Telomere Ttaggg
    Publish Year:1989
    10.1073/pnas.86.18.7049
  30. Nature
    https://www.nature.com/articles/s41586-024-07501-1

    A disease-associated gene desert directs macrophage …

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