ttaggg sequence and inflammation - Search
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  2. Studies of ttaggg sequence and inflammation
    National Center for Biotechnology Information
    Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses
    Gene therapy holds exciting promise for treating many genetic disorders, but host immune responses pose a major challenge for in vivo gene transfer (1). Whereas adeno-associated viral (AAV) vectors are known to be less immunogenic than other viral vectors
    Author: Ying Kai Chan…
    Published: 2021/02/02
    DOI: 10.1126/scitranslm…
    National Center for Biotechnology Information
    A suppressive oligodeoxynucleotide expressing TTAGGG motifs modulates cellular energetics through the mTOR signaling pathway
    The immunosuppressive ODN A151 profoundly affects mTOR signaling Keywords: A151 ODN, immunometabolism, immunosuppression, microarray
    Author: Volkan Yazar, …
    Published: 2020/01
    Publication: Int Immun…
    National Center for Biotechnology Information
    Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive TTAGGG Motifs Inhibit AIM2 Inflammasome Activation
    Synthetic oligodeoxynucleotides comprised of the immunosuppressive motif TTAGGG block TLR9 signaling, prevent STAT1 and STAT4 phosphorylation and attenuate a variety of inflammatory responses in vivo. Here, we demonstrate that such suppressive oligodeoxynucleotides
    Author: John J. Kamin…
    Published: 2013/10/10
    DOI: 10.4049/jimmunol.…
    ScienceDirect
    Invited review Structure, mechanism and therapeutic utility of immunosuppressive oligonucleotides
    Synthetic oligodeoxynucleotides that can down-regulate cellular elements of the immune system have been developed and are being widely studied in preclinical models. These agents vary in sequence, mechanism of action, and cellular target(s) but share
    Published: 2016/03/01
    Cited By: 26
    Page Count: 10
    PubMed
    Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes
    Type I interferon (IFN) is a critical mediator of autoimmune diseases such as systemic lupus erythematosus (SLE) and Aicardi-Goutières Syndrome (AGS). The recently discovered cyclic-GMP-AMP (cGAMP) synthase (cGAS) induces the production of type I IFN
    Author: Folkert Steinh…
    Published: 2018/4
    Keywords: Autoimmun…
    PubMed
    Telomere shortening during aging: Attenuation by antioxidants and anti-inflammatory agents
    Telomeres are a repeated sequence -of bases found at the ends of chromosomes. In humans, this sequence is TTAGGG, which is repeated over 2000 times. Telomeres protect the ends chromosomes from fusion with nearby chromosomes, and allow effective replication
    Author: Kedar N Prasad
    Published: 2017/6
    Keywords: Aging; Anti …
    National Center for Biotechnology Information
    Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes
    The recognition of microbial DNA is a major mechanism by which the immune system detects pathogens. Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that activates innate immune responses through production of the second messenger cGAMP,
    Author: Folkert Steinh…
    Published: 2018/04
    DOI: 10.1002/eji.20174…
    National Center for Biotechnology Information
    Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats
    The immune system plays a fundamental role in both the development and pathobiology of stroke. Inflammasomes are multiprotein complexes that have come to be recognized as critical players in the inflammation that ultimately contributes to stroke severity.
    Author: Jing Zhao, Yo…
    Published: 2015
    Publication: PLoS On…
    PubMed
    A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
    A highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library. Quantitative hybridization to chromosomes sorted by flow cytometry indicates that comparable amounts of this sequence are present
    Author: R K Moyzis
    Published: 1988/9
    Keywords: National In…
    National Center for Biotechnology Information
    Conservation of the human telomere sequence (TTAGGG)n among vertebrates.
    To determine the evolutionary origin of the human telomere sequence (TTAGGG)n, biotinylated oligodeoxynucleotides of this sequence were hybridized to metaphase spreads from 91 different species, including representative orders of bony fish, reptiles,
    Author: J Meyne, R L …
    Published: 1989/09
    Publication: Proc Natl …
     
  3. PubMed
    https://pubmed.ncbi.nlm.nih.gov/31633763

    A suppressive oligodeoxynucleotide expressing TTAGGG motifs …

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    Suppressive oligodeoxynucleotides containing TTAGGG …
    pubmed.ncbi.nlm.nih.gov
    ODN TTAGGG A151 | TLR9, AIM2, IFI16 & cGAS antagonist …
    invivogen.com
    ODN TTAGGG (ODN A151) | TLR Antagonist | …
    medchemexpress.com
    Synthetic Oligodeoxynucleotides Containing Suppressive …
    journals.aai.org
    ODN TTAGGG (A151) - InvivoGen
    invivogen.com
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  4. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409505

    Engineering adeno-associated viral vectors to evade innate …

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    Engineering adeno-associated virus vectors for gene therapy
    nature.com
    Adeno-associated virus vector as a platform for gene …
    nature.com
    Recommended to you based on what's popular • Feedback
  5. Science | AAAS
    https://www.science.org/doi/pdf/10.1126/...
    [PDF]

    GENE THERAPY Engineering adeno-associated viral …

  6. Nature
    https://www.nature.com/articles/s41467-024-49072-9

    A persistent variant telomere sequence in a human pedigree

    Tags:
    Conserved Dna Sequence
    TTAGGG
  7. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185194

    A suppressive oligodeoxynucleotide expressing TTAGGG motifs …

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    Publish Year:2020
    Odn A151
    10.1093/intimm/dxz059
    Published:2020/01
  8. Science | AAAS
    https://www.science.org/doi/10.1126/scitranslmed.abd3438

    Engineering adeno-associated viral vectors to evade innate

    Tags:
    Viral Vectors
    Publish Year:2021
    Adenovirus Vector Production Titer
  9. People also ask
    Do TTAGGG proteins bind to nontelomeric DNA sequences?However, very little is known on the binding of these proteins to nontelomeric DNA sequences. The TTAGGG DNA repeat proteins 1 and 2 (TRF1 and TRF2) bind to mammalian telomeres as part of the shelterin complex and are essential for maintaining chromosome end stability.

    The human TTAGGG repeat factors 1 and 2 bind to a subset of ... - Natu…

    nature.com
    What causes elevated TTG?
    primaryExpertImage

    Dr. Howard E. LeWine

    M.D. Chief Medical Editor, Harvard Health Publishing · 40 years of exp

    An elevated blood level of TTG (tissue transglutaminase) supports a diagnosis of celiac disease. Celiac disease (also called gluten-sensitive enteropathy) is an intestinal disorder in which the body cannot tolerate gluten. Gluten is a natural protein in many grains, including wheat, barley, rye and oats. People with celiac disease have an immune reaction that is triggered by gluten. The immune reaction causes inflammation at the surface of the small intestine where it damages the surface of the intestine. When they are damaged, the intestine cannot absorb nutrients properly.
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    microsoftstart.msn.com
    What does TTAGGG stand for?A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. A highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library.

    A highly conserved repetitive DNA sequence, (TTAGGG)n, present at th…

    pnas.org
    How many times a chromosome is TTAGGG repeated?In humans, this sequence is TTAGGG, which is repeated over 2000 times. Telomeres protect the ends chromosomes from fusion with nearby chromosomes, and allow effective replication of DNA. Each time a cell divides, 25-200 base pairs are lost from the terminal sequence of chromosomes.

    Telomere shortening during aging: Attenuation by antioxidants and anti

    pubmed.ncbi.nlm.nih.gov
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  10. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878640

    Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive …

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    Publish Year:2013
    10.4049/jimmunol.1300530
    Published:2013/10/10
  11. American Association of Immunologists
    https://journals.aai.org/jimmunol/article/…

    Synthetic Oligodeoxynucleotides Containing …

    WebOct 1, 2013 · Synthetic oligodeoxynucleotides (ODNs) comprised of the immunosuppressive motif TTAGGG block TLR9 signaling, prevent STAT1 and STAT4 phosphorylation and attenuate a variety of inflammatory …

    Tags:
    TTAGGG
    TLR9
  12. Nature
    https://www.nature.com/articles/s41419-023-06140-0

    Inhibition of cGAS–STING pathway alleviates ... - Nature

  13. ScienceDirect
    https://www.sciencedirect.com/science/article/abs/...

    Structure, mechanism and therapeutic utility of …

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    Defne Bayik, Ihsan Gursel, Dennis M. Klinman
    Publish Year:2016
  14. PNAS
    https://www.pnas.org/doi/10.1073/pnas.85.18.6622

    A highly conserved repetitive DNA sequence, (TTAGGG)n, …

    Tags:
    Conserved Dna Sequence
    Highly Repetitive Sequence
    Repetitive DNA
  15. PubMed
    https://pubmed.ncbi.nlm.nih.gov/29215161

    Suppressive oligodeoxynucleotides containing TTAGGG motifs …

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    Publish Year:2018
  16. UCL Discovery
    https://discovery.ucl.ac.uk/id/eprint/10121916/31/Dick_Main Text Final.pdf
    [PDF]

    Engineering adeno-associated viral vectors to evade innate …

    Tags:
    Viral Vectors
    TLR9
  17. Nature
    https://www.nature.com/articles/cr201140

    The human TTAGGG repeat factors 1 and 2 bind to a subset of

    Tags:
    TTAGGG Repeat Factors
    Publish Year:2011
    Ttaggg Repeats in What Cell
  18. springeropen.com
    https://jmhg.springeropen.com/articles/10.1186/s43042-022-00335-4

    Telomere attrition and inflammation: the chicken and the egg …

  19. PubMed
    https://pubmed.ncbi.nlm.nih.gov/28431907

    Telomere shortening during aging: Attenuation by antioxidants

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    Kedar N. Prasad, Meixia Wu, Stephen C. Bondy
    Publish Year:2017
  20. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386451

    Suppressive oligodeoxynucleotides containing TTAGGG motifs …

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    Publish Year:2018
    Published:2018/04
  21. Oxford Academic
    https://academic.oup.com/jhered/article/93/4/282/2187315

    Conservation of (TTAGG)n Telomeric Sequences Among Ants …

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    P. Lorite, J. A. Carrillo, T. Palomeque
    Publish Year:2002
  22. PNAS
    https://www.pnas.org/doi/10.1073/pnas.86.18.7049

    Conservation of the human telomere sequence (TTAGGG)n …

  23. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608557

    Synthetic Oligodeoxynucleotides Containing Multiple Telemeric …

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    Publish Year:2015
    10.1371/journal.pone.0140772
    Published:2015
  24. Cell Communication and Signaling
    https://biosignaling.biomedcentral.com/articles/10...

    Molecular mechanisms of aging and anti-aging strategies

    Tags:
    Inflammation
    DNA
  25. PubMed
    https://pubmed.ncbi.nlm.nih.gov/3413114

    A highly conserved repetitive DNA sequence, (TTAGGG)n, …

    Tags:
    Conserved Dna Sequence
    Human Telomere Ttaggg
    Highly Repetitive Sequence
  26. Nature
    https://www.nature.com/articles/cr201140.pdf
    [PDF]

    The human TTAGGG repeat factors 1 and 2 bind to a subset …

    Tags:
    Publish Year:2011
    TTAGGG Repeat Factors
  27. Annals of the Rheumatic Diseases
    https://ard.bmj.com/content/early/2024/05/30/ard-2024-225630

    Association between premature vascular smooth muscle cells …

  28. Microbiome
    https://microbiomejournal.biomedcentral.com/...

    The interrelation between microbial immunoglobulin coating, …

  29. Nature
    https://www.nature.com/articles/6887090

    Physical mapping of rDNA genes, ( TTAGGG )n telomeric …

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    Roberto Vitturi, Maria Stella Colomba, Anna Pirrone, Angelo Libertini
    Publish Year:2000
  30. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC297991

    Conservation of the human telomere sequence (TTAGGG)n …

    Tags:
    Human Telomere Ttaggg
    Publish Year:1989
    10.1073/pnas.86.18.7049
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