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Choosing Among Type II Diabetes Mouse Models - The Jackson …
JAX has been distributing mouse models for type II diabetes (Non-insulin Dependent Diabetes; NIDD; T2D) since the 1960s, and today there are several models to choose from. Unfortunately, no single diabetic mouse model recapitulates all of the features or complications of human diabetes. See more
First some orientation: Diabetes in humans typically develops through a progressive series of increasingly severe stages (or phases): • Pre-diabetes: Characterized by impaired glucose tolerance – difficulty clearing glucose following a meal – … See more
Mice homozygous for the obese (Lepob) and the diabetes (Leprdb) mutations were the earliest diabetic mouse models characterized, and … See more
We often describe ob/ob, db/db, and Ay mice as “monogenic” models because their obese and diabetic phenotypes derive from single … See more
Obesity is one of the greatest risk factors linked to diabetes in humans, and similar to humans, some mouse strains become obese when fed high-fat or so-called “Western” diets. Among mouse strains, C57BL/6 is among the most sensitive to this diet-induced … See more
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In Vivo Rodent Models of Type 2 Diabetes and Their Usefulness …
WEBFeb 28, 2019 · The inbred C57BL/6J mouse strain, first described in 1988, is a polygenic obesity-prone mouse strain widely used as a model for DIO because it is prone to …
- Author: Jia-You Fang, Chih-Hung Lin, Tse-Hung Huang, Shih-Yi Chuang
- DOI: 10.3390/nu11030530
- Publish Year: 2019
- Publication: Nutrients. 2019 Mar; 11(3): 530.
- Studies of type 2 diabetes mouse models
Experimental animal models for diabetes and its related …
WEBAug 24, 2021 · NOD-mouse, diabetes prone BB rats, KDP rat, LETL rat and LEW-iddm rat are the widely used animal models of spontaneous diabetes for studying the …
- Author: Chidhambara Priya Dharshini Kottaisamy, Divya S. Raj, V. Prasanth Kumar, Umamaheswari Sankaran
- Publish Year: 2021
Type 2 Diabetes Animal Studies | Charles River
WEBThe ob/ob and db/db mouse models are popular, well characterized models of Type 2 Diabetes (T2D). Charles River also offers NASH models, Diet-Induced Obesity and …
A new mouse model of type 2 diabetes mellitus established …
WEBDec 1, 2021 · A stable induced type 2 diabetes model (T2DM) still needs to be explored for basic and clinical research, due to nonuniform model methods and unstable …
Animal models of obesity and diabetes mellitus - Nature
WEBJan 19, 2018 · 133 Altmetric. Metrics. Key Points. Development of safe and potent therapeutics is required to combat the obesity and diabetes mellitus pandemic. Animal …
Mammalian models of diabetes mellitus, with a focus on type 2 …
WEBMar 20, 2023 · The most frequently used large animal models include pigs, dogs and cats; most diabetic cats have a disease entity similar to human type 2 diabetes mellitus, …
A novel model mouse for type 2 diabetes mellitus with early onset …
WEBJul 28, 2022 · Various mouse models of type 2 diabetes have been established, but few of these show early onset and persistent hyperglycemia. We have established a congenic …
A new mouse model of type 2 diabetes mellitus established …
WEBDec 1, 2021 · By adding glucocorticoids to the HFD + STZ model and optimized design, we established a mouse model of T2DM, which has a stable effect on insulin resistance and …
The use of mice in diabetes research: The impact of physiological ...
WEBOct 6, 2021 · Therefore, models of T2D mimic insulin resistance and/or β-cell failure with severity ranging from glucose intolerance (pre-diabetes) to overt diabetes (established …
Establishment and Assessment of Mice Models of Type 2 …
WEBJun 20, 2017 · Abstract. Objective To establish type 2 diabetes mellitus (T2DM)KM mouse models via the combined use of high-calorie diet and multiple administration of low-dose …
Mouse models and type 2 diabetes: translational opportunities
WEBIn this review we discuss the use of the mouse to clarify human genome-wide association study loci, understand genes and pathways involved in type 2 diabetes, and uncover …
Use of mouse models in studying type 2 diabetes mellitus
WEBThe use of mouse models in medical research has greatly contributed to our understanding of the development of type 2 diabetes mellitus and the mechanisms of …
Mouse Models of Type 2 Diabetes Mellitus in Drug Discovery
WEBMay 6, 2016 · The mouse has proven to be a reliable model for discovering and validating new treatments for type 2 diabetes mellitus. We review here commonly used methods …
A new mouse model of type 2 diabetes mellitus established …
WEBDec 1, 2021 · Abstract. Aim: A stable induced type 2 diabetes model (T2DM) still needs to be explored for basic and clinical research, due to nonuniform model methods and …
Mouse models and type 2 diabetes: translational opportunities
WEBJun 29, 2011 · Mouse models and type 2 diabetes: translational opportunities. Published: 29 June 2011. Volume 22 , pages 390–400, ( 2011 ) Cite this article. Download PDF. …
Experimental animal models for diabetes and its related …
WEBAug 24, 2021 · NOD-mouse, diabetes prone BB rats, KDP rat, LETL rat and LEW-iddm rat are the widely used animal models of spontaneous diabetes for studying the …
Transgenic type2 diabetes mouse models for in vivo
WEBMar 1, 2023 · RoGFP-expressing transgenic type 2 diabetes mouse models are effective and convenient tools for measuring hepatic mitochondrial redox statuses in vivo. These …
The use of animal models in diabetes research - PMC
WEBType 2 diabetes is modelled in both obese and non-obese animal models with varying degrees of insulin resistance and beta cell failure. This review outlines some of the …
Mouse Models of Type 2 Diabetes | SpringerLink
WEBMouse Models of Type 2 Diabetes. Domenico Accili M.D. & Byung-Chul Park Ph.D. Chapter. 162 Accesses. Part of the Endocrine Updates book series (ENDO,volume 10) …
Mouse Models of Type 2 Diabetes Mellitus in Drug Discovery
WEBHelene Baribault 1. Show more details. Mouse Models for Drug Discovery. |. Citations: 7. PDF Full Text Related articles. Abstract. Type 2 diabetes is a fast-growing epidemic in …
Impact of Diet on the KK-Ay Mouse Model of Type 2 Diabetes
WEB6 days ago · Along with a variety of other systemic effects, type 2 diabetes increases fracture risk. This aspect of type 2 diabetes has become a topic of interest in preclinical …
New therapeutic targets to fight type 2 diabetes | ScienceDaily
WEB1 day ago · Sep. 14, 2022 — Treating mice models of insulin-dependent diabetes mellitus (a condition found primarily in type 1 diabetes) with a combination of leptin and a drug …
Mouse Models of Type 2 Diabetes Mellitus in Drug Discovery
WEBHowever, several emerging areas of discovery research are showing promises with the development of novel classes of antidiabetic drugs.The mouse has proven to be a …
Effects of Nox4 upregulation on PECAM-1 expression in a mouse …
WEBWe found that overexpression of Nox4 increases PECAM-1 mRNA but has no effect on its protein expression in the mouse retina, BMECs, or HRECs. Furthermore, PECAM-1 …
Systematic review and meta-analysis of mouse models of …
WEBMay 27, 2020 · Mouse models are frequently used to study diabetes-associated ulcers, however, whether these models accurately simulate impaired wound healing has not …
Pharmaceuticals | Free Full-Text | Quercetin and Kaempferol as …
WEB1 day ago · Diabetes, a multifactorial metabolic disorder, demands the discovery of multi-targeting drugs with minimal side effects. This study investigated the multi-targeting …
Capillary contact points determine beta cell polarity, control ...
WEBMay 30, 2024 · In terms of disease, islet capillary structure changes in type two diabetes, described as a decrease in capillaries in rodents [19, 23] or an increase in humans . In …
Studying intramuscular fat deposition and muscle regeneration: …
WEBMay 29, 2024 · Intramuscular fat (IMAT) infiltration, pathological adipose tissue that accumulates between muscle fibers, is a shared hallmark in a diverse set of diseases …
Luteolin Ameliorates Nonalcoholic Fatty Liver Disease via …
WEB4 days ago · A mouse model with NAFLD was induced by Western diet (WD) and carbon tetrachloride (CCl 4) injection.Twenty-four mice were distributed into three groups …
Generation of a lethal mouse model expressing human ACE2 …
WEBMay 31, 2024 · This research aimed to create a type of mouse that is very prone to SARS-CoV-2 infection, the virus that causes COVID-19. Scientists from two Korean research …
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