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- Learn more:✕This summary was generated using AI based on multiple online sources. To view the original source information, use the "Learn more" links.An increase in the severity of a disease or in any of its signs or symptoms.medical-dictionary.thefreedictionary.com/exacerbat…Exacerbation: A worsening. In medicine, exacerbation may refer to an increase in the severity of a disease or its signs and symptoms.www.rxlist.com/exacerbation/definition.htm
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