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  8. People also ask
    How does the TSC1-TSC2 complex promote mTORC2 activation?The molecular mechanism through which the TSC1–TSC2 complex promotes mTORC2 activation, and whether some of the pathways that regulate the complexes ability to inhibit mTORC1 also effect its activation of mTORC2, are currently unknown.

    The TSC1 – TSC2 complex: a molecular switchboard controlling cell gr…

    ncbi.nlm.nih.gov
    What is TSC1 TSC2 mTORC1?Their gene products form a complex that has become the focus of many signal transduction researchers. The TSC1–TSC2 (hamartin–tuberin) complex, through its GAP (GTPase-activating protein) activity towards the small G-protein Rheb (Ras homologue enriched in brain), is a critical negative regulator of mTORC1 (mammalian target of rapamycin complex 1).

    The TSC1 – TSC2 complex: a molecular switchboard controlling cell gr…

    ncbi.nlm.nih.gov
    Is the TSC1-TSC2 complex a critical upstream inhibitor of mTORC1?Although it is now clear that the TSC1–TSC2 complex is a critical upstream inhibitor of mTORC1, a role for this complex in the regulation of mTORC2 and its subsequent phosphorylation of Akt has been more difficult to ascertain.

    The TSC1 – TSC2 complex: a molecular switchboard controlling cell gr…

    ncbi.nlm.nih.gov
    Does a mouse model of TSC1 reveal sex-dependent lethality from liver hemangiomas?A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in TSC1 null cells. Hum Mol Genet. 2002;11:525–534. [ PubMed] [ Google Scholar] 46. Kenerson HL, Aicher LD, True LD, Yeung RS.

    The TSC1 – TSC2 complex: a molecular switchboard controlling cell gr…

    ncbi.nlm.nih.gov
    What is TSC1 & TSC2?TSC1 and TSC2 are disease genes for tuberous sclerosis complex (TSC), a neurocutaneous disorder in which hamartomas and other benign tumors form in many organs including brain, skin, and kidneys. Neurological manifestations including autism, intellectual disability, and epilepsy are also common. (See 'Overview of tuberous sclerosis complex' below.)

    Gene test interpretation: TSC1 and TSC2 (tuberous sclerosis ... - UpToD…

    uptodate.com
    Are TSC1 and TSC2 mutations related to INR signalling?Indeed Tsc1 and Tsc2 mutations and co-overexpression exhibited strong genetic interactions with components of InR signalling, including InR, PTEN (phosphatase and tensin homologue deleted on chromosome 10), Akt (also known as protein kinase B) and S6K (70 kDa ribosomal protein S6 kinase; also known as p70S6K), for the control of cell growth.

    The TSC1 – TSC2 complex: a molecular switchboard controlling cell gr…

    ncbi.nlm.nih.gov
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  11. UpToDate
    https://www.uptodate.com/contents/tuberous-sclerosis-complex

    Tuberous sclerosis complex: Clinical features - UpToDate

  12. Wikipedia
    https://en.wikipedia.org/wiki/Tuberous_sclerosis_protein

    Tuberous sclerosis protein - Wikipedia

  13. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735030

    The TSC1–TSC2 complex: a molecular switchboard controlling …

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  16. UpToDate
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    Gene test interpretation: TSC1 and TSC2 (tuberous sclerosis

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